TY - T1的独特模式并存病的儿童发病与成人发病多发性硬化症使用大量真实的女士人口(2287)JF -神经学乔-神经学六世- 96 - 15补充SP - 2287 AU -玛丽Rensel AU -德文康威盟莎拉命名教皇Y1 - 2021/04/13 UR - http://n.neurology.or首页g/content/96/15_Supplement/2287.abstract N2 -目的:定义疾病模式在一个大的,现实世界人口儿科(盐)和成人发病多发性硬化症(急性中耳炎)患者疾病持续时间相匹配。背景:盐低发病率模式捕获在一个大的现实世界人口,女士没有报道,可能影响疾病的严重程度。多发性硬化症的合作伙伴推进技术和卫生解决方案(路径)女士是一个多中心倡议由生原体并存病,社会人口,NeuroOL、表型和女士收集纵向性能措施。设计/方法:女士路径数据削减11(2020年3月)评估。患者急性中耳炎和盐低匹配5:1基于疾病持续时间。的医疗和心理并发症比较通过卡方测试或Wilcoxon曼惠特尼秩和检验。线性回归是用来确定预测疾病的存在。结果:共有14878名患者被确认。匹配后,有3455名急性中耳炎(平均年龄51.2岁,63%的白人,平均35岁dx) vs 690酸盐(平均年龄35.7,40%的白人,意味着dx年龄)。之间没有显著差异的人群心理健康并存病,慢性阻塞性肺病或血脂异常即使吸烟中耳炎患者中更常见。有显著差异的群体对糖尿病(p =。0075, 4 vs 44% ) and cardiac comorbidities (p=<0.0001) 19 vs 42%). Measures that predicted depression included: age, smoking status, sleep, fatigue, anxiety, disease stigma, and upper and lower extremity function. Measures that predicted anxiety included: sex, race, insurance type, patient reported disability level, sleep, depression, fatigue, walking speed, and disease stigma.Conclusions: POMS had similar rates of mental health and some medical comorbidities despite younger median age. POMS had lower rates of smoking, cardiac and diabetes. Mental health comorbidities in both groups were predicted by demographic, functional, and quality of life outcomes. Prevention, improved detection and treatment of comorbidities is important in both POMS and AOMS.Disclosure: Dr. Rensel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Rensel has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for msaa. Dr. Rensel has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Rensel has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for biogen. Dr. Rensel has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Neohealth . Dr. Rensel has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme . Dr. Rensel has received stock or an ownership interest from Brain Ops Group LLC. Dr. Rensel has received stock or an ownership interest from Brain Fresh LLC . The institution of Dr. Rensel has received research support from medimmune. The institution of Dr. Rensel has received research support from NMSS. The institution of Dr. Rensel has received research support from Novartis . The institution of Dr. Rensel has received research support from Biogen. The institution of Dr. Rensel has received research support from genentech. Dr. Conway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis Pharmaceuticals. Dr. Conway has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Planchon Pope has nothing to disclose. ER -