TY -的T1 - AQP4-Ab患者怀孕,MOG-Ab或双重否定Neuromyelitis视障碍JF -神经学乔-神经- 10.1212 / WNL。首页0000000000011744 SP - 10.1212 / WNL。0000000000011744 AU -尼古拉斯Collongues盟塞西莉亚阿尔维斯做的“政府改造”非盟-伯特兰Bourre盟医学博士;Damien Biotti AU -罗曼Marignier盟- Ana马丁斯席尔瓦盟Ernestina桑托斯AU -伊丽莎白Maillart AU -卡洛琳Papeix盟杰奎琳宫非盟-玛丽亚伊莎贝尔·雷特盟杰罗姆·德·Seze Y1 - 2021/02/15 UR - //www.ez-admanager.com/content/early/2021/02/24/WNL.0000000000011744.abstract N2 -目的:分析怀孕的影首页响视neuromyelitis谱系障碍(NMOSD)根据患者serostatus和免疫抑制疗法(IST)。方法:我们进行了一个回顾国际多中心研究NMOSD患者。患者检测aquaporin-4 (AQP4)和髓少突细胞糖蛋白(MOG)抗体(Ab)。信息怀孕时报道NMOSD发作之前或在怀孕期间或12个月发生产后(PP)。平均年复发率(ARR)计算在怀孕前的12个月中,每三个月妊娠和事件页。如流产、堕胎和子痫前期报道。是被认为是如果在怀孕期间或怀孕前的3个月。结果:我们包括89名怀孕(46 AQP4-Ab, 30 MOG-Ab和13没有Ab)在58个NMOSD病人。比怀孕前时期,加勒比海盗是在怀孕期间每个serostatus组低和高PP期间患者AQP4-Ab(术中,0.01)。百分之四十八(n = 31)的妊娠发生在怀孕期间坚持少和这些患者复发和PP的12个月里比未经治疗的患者(26%比53%,p = 0.04)。 Miscarriages occurred in 10 (11%) pregnancies, and were mainly in patients with AQP4-Ab (with or without IST) and a previous history of miscarriage. Preeclampsia was reported in two (2%) patients who were AQP4-Ab positive.Conclusion: We found a rebound in the ARR during the first PP trimester that was higher than the pre-pregnancy period only in AQP4-Ab-positive patients. Taking IST just before or during pregnancy reduces the risk of relapses in these conditions. ER -