@article {Chene1180作者={秦陈Val j·劳和布拉德利·f·Boeve斯科特·a·Przybelski东寺Miyagawa和马修·l·Senjem克利福德·r·杰克,小和蒂莫西·g . Lesnick沃尔特·k·克雷默和朱莉·a .字段Hoon-Ki Min和克里斯托弗·g·施瓦兹和Jeffrey l .冈特和乔纳森Graff-Radford Rodolfo Savica和David s . Knopman大卫琼斯和坦尼斯j . Ferman尼尔r . Graff-Radford和罗纳德·c·彼得森Kejal Kantarci}, title ={β-Amyloid宠物和123年i-fp-cit SPECT在轻度认知障碍的风险路易体痴呆},体积={96}={8},页面= {e1180——e1189} = {2021}, doi = {10.1212 / WNL。出版商0000000000011454}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的来确定相关的临床表型β-amyloid宠物和多巴胺转运体成像(123 i-首页fp-cit SPECT)发现轻度认知障碍(MCI)和路易体痴呆的临床特征与核心(下文;MCI-LB)。方法MCI患者至少有1下文的核心临床特征(n = 34)分为β-amyloid +或-和123年i-fp-cit SPECT D +和D -团体基于先前建立异常减少点与匹兹堡化合物B +宠物标准摄入值比率(加以SUVR) > = 1.48和D +硬膜z分数123 i-fp-cit SPECT DaTQUANT \ < -0.82。个别患者MCI-LB掉进1的4组:+ D +, + D -,模拟+,或模拟-。对数转换加以SUVR和壳核z分数检测对病人的特点。结果模拟+生物标志物概要文件是最常见的(38.2 \ %),后跟一个+ D +(26.5 \ %)和模拟- (26.5 \ %)。最常见的是+ D -生物标志物概要(8.8 \ %)。+组老,更高频率的APOEε4运营商,细微精神状态检查较低分数比A -。D +组更可能可能REM睡眠行为障碍。低壳DaTQUANT z分数和低加以SUVRs高出独立与统一帕金森{\ textquoteright}疾病评级Scale-III分数。结论多数患者MCI-LB特点是低β-amyloid沉积和多巴胺能减少活动。 β-Amyloid PET and 123I-FP-CIT SPECT are complementary in characterizing clinical phenotypes of patients with MCI-LB.ADRC=Alzheimer{\textquoteright}s Disease Research Center; DLB=dementia with Lewy bodies; LB=Lewy bodies; MCALT=Mayo Clinic Adult Lifespan Template; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; PiB=Pittsburgh compound B; RBD=REM sleep behavior disorder; SUVR=standardized uptake value ratio; UPDRS=Unified Parkinson{\textquoteright}s Disease Rating Scale; VOI=volume of interest}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/96/8/e1180}, eprint = {//www.ez-admanager.com/content/96/8/e1180.full.pdf}, journal = {Neurology} }