@article {Vallat214作者= {jean - michel Vallat和马蒂尔德杜谢恩Philippe Corcia和劳伦斯·理查德和卡莉玛Ghorab Laurent Magy和圣{\ ' e} phane马西斯},title = {Paraproteinemic神经病变的病理生理机制的广泛},体积={96}={5},页面= {214 - 225}= {2021},doi = {10.1212 / WNL。出版商0000000000011324}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={单克隆丙种球蛋白病是经常遇到的。首页这种类型的血液异常可能是轻微的,称为单克隆丙种球蛋白病待定意义或与之相关的不同类型的血液恶性肿瘤。周围神经病变的协会与单克隆丙种球蛋白病也相当普遍,和血液病可能发现周围神经病变的一个调查。在这种情况下,有必要确定的确切性质血液过程为了不漏掉一个恶性疾病,从而启动适当的治疗(与血液学家和肿瘤学家)。在这方面,神经活检(在个案基础上讨论)是很有价值的管理这样的病人。因此我们提出的目标,在这种情况下神经活检的主要利益。广告=淀粉样变存款;艾尔=原发性淀粉样变;BTU = B {\“u} hlmann效价单位;CANOMAD =慢性运动失调的神经病变,眼肌麻痹,IgM副蛋白,冷凝集素和disialosyl抗体;CIDP =慢性炎性脱髓鞘多神经根神经病; CMAP=compound muscle action potentials; CRAB=hypercalcemia, renal insufficiency, anemia, and bone lesions; DADS=distal acquired demyelinating symmetric; DIF=direct immunofluorescence; EFNS/PNS=European Federation of Neurological Societies/ Peripheral Nerve Society; EM=electron microscopy; GD=disialoganglioside; GQ=quadrisialoganglioside; GT=trisialoganglioside; HC=heavy chain; HNK1=human natural killer-1; Ig=immunoglobulin; LC=light chain; LM=light microscopy; LRW=London resin white; MAG=myelin-associated glycoprotein; MG=monoclonal gammopathy; MGUS=monoclonal gammopathy of undetermined significance; MYD88=myeloid differentiation primary response 88; NB=nerve biopsy; NCS=nerve conduction study; PN=peripheral neuropathy; POEMS=Polyneuropathy, Organomegaly, Endocrinopathy, presence of M-protein and Skin changes; SFN=small fiber neuropathy; SGLPG=sulfate-3-glucuronyl lactosaminyl paragloboside; SGPG=sulfate-3-glucuronyl paragloboside; SNAP=sensory nerve action potential; VEGF=vascular endothelial growth factor; WM=Waldenstr{\"o}m macroglobulinemia; WML=widenings of the myelin lamellae}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/96/5/214}, eprint = {//www.ez-admanager.com/content/96/5/214.full.pdf}, journal = {Neurology} }