@article {Whitwelle3190作者={珍妮弗·l . Whitwell和Nirubol Tosakulwong克里斯托弗·c·施瓦兹和马修·l·Senjem Anthony j . Spychalla玛丽和约瑟夫·r·达菲和Jon Graff-Radford m Machulda和布拉德利f Boeve David s . Knopman和罗纳德·c·彼得森Val克利福德·r·j·劳和杰克,小丹尼斯·w·迪克森和约瑟夫·e·帕里和基思·a .约瑟夫},title ={纵向解剖、功能和分子特征选择疾病表型},体积={95}={24},页面= {e3190——e3202} = {2020}, doi = {10.1212 / WNL。出版商0000000000010948}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的描述纵向MRI和PET异常autopsy-confirmed选择神经退化疾首页病(PiD)和确定模式差异对临床综合症。方法17 PiD患者发现他临死前的MRI(8与行为变异额颞叶痴呆(bvFTD-PiD) 6与迟滞型/ agrammatic原发性进行性失语(naPPA-PiD), 1与语义原发性进行性失语,1非保密原发性进行性失语,和1 corticobasal综合症)。13个病人串行MRI总共56核磁共振成像,7 [18 f]氟脱氧葡萄糖PET, 4匹兹堡化合物B(加以宠物,和1病人[18 f] flortaucipir宠物。横向和纵向比较的灰质体积和新陈代谢bvFTD-PiD之间进行,naPPA-PiD和控制。皮质加以总结计算来确定β-amyloid积极性。bvFTD-PiD和naPPA-PiD组结果显示不同焦距的容积损失和在疾病早期代谢减退,bvFTD-PiD涉及双边前额叶和前颞皮层naPPA-PiD涉及左额下回、岛叶和前额皮质。然而,合并模式随着时间的推移,逐渐蔓延至前额叶和naPPA-PiD前颞叶,颞叶,它和最终参与运动皮层,顶叶在两组。额颞叶萎缩率比naPPA-PiD bvFTD-PiD更快。一个病人是β-amyloid {\ textendash}看好宠物较低的老年痴呆症neuropathologic改变尸检。Flortaucipir宠物显示,额颞叶白质高吸收。Conclusion Patterns of atrophy and hypometabolism differ in PiD according to presenting syndrome, although patterns of neurodegeneration appear to converge over time.Aβ=β-amyloid; AUROC=area under the receiver operating characteristic curve; bvFTD=behavioral variant of frontotemporal dementia; FDG-PET=[18F]fluorodeoxyglucose PET; FDR=false discovery rate; FOV=field of view; FWE=familywise error; FWHM=full width at half maximum; MCALT=Mayo Clinic Adult Lifespan Template; MCSA=Mayo Clinic Study of Aging; MPRAGE=magnetization-prepared rapid acquisition gradient echo; naPPA=nonfluent/agrammatic variant of primary progressive aphasia; PiD=Pick disease; PPA=primary progressive aphasia; ROI=region of interest; SUVR=standardized uptake value ratio; svPPA=semantic variant of primary progressive aphasia; TE=echo time; TI=inversion time; TR=repetition time}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/95/24/e3190}, eprint = {//www.ez-admanager.com/content/95/24/e3190.full.pdf}, journal = {Neurology} }