TY -的T1 - CSF协会orexin-A水平和患者夜间睡眠稳定抽动JF -神经学乔-神经病学SP - e2900 LP - e2911做- 10.1212 / WNL。首页0000000000010743六世- 95 - 21 AU -露西Barateau盟里吉斯·洛佩兹盟Sofiene Chenini AU - Anna-Laura Rassu AU - Sabine朔尔茨盟曼Lotierzo AU - jean - paul Cristol盟Isabelle Jaussent盟-伊夫Dauvilliers Y1 - 2020/11/24 UR - //www.ez-admanager.com/content/95/21/e2900.abstract N2 -目的探首页讨脑脊液orexin-A之间的关联(ORX)水平和标记的夜间睡眠稳定,通过多导睡眠图评估。方法夜间多导睡眠图数据和ORX水平300无毒的参与者(55%男性,29.9±15.5年,ORX水平155.1±153.7 pg / mL)收集抽动。几个标记的夜间睡眠稳定进行了分析:睡眠和醒来发作和睡眠/唤醒转换。组分类根据ORX水平、2类(缺乏≤110;110),在tertiles(≤26日,26 - 254,在254年),并使用逻辑回归模型相比。结果调整年龄、性别和体重指数。结果我们发现更多的后发作(43 vs 25日p & lt;0.0001),睡眠发作(43 vs 25.5, p & lt;0.0001),和索引的睡眠发作/小时的睡眠时间,但下标起床后次/小时(41.4 vs 50.6, p & lt;0.0001),患者ORX缺乏症。 The percentage of wake bouts <30 seconds was lower (51.3% vs 60.8%, p < 0.001) and of wake bouts ≥1 minutes 30 seconds higher (7.7% vs 6.7%, p = 0.02) when ORX deficient. The percentage of sleep bouts ≤14 minutes was higher (2–5 minutes: 23.7% vs 16.1%, p < 0.0001), and of long sleep bouts lower (>32 minutes 30 seconds: 7.3% vs 18.3%, p < 0.0001), when ORX deficient. These findings were confirmed when groups were categorized according to ORX tertiles, with a dose–response effect of ORX levels in post hoc comparisons, and in adjusted models.Interpretation This study shows an association between ORX levels and nocturnal sleep stabilization in patients with hypersomnolence. Sleep and wake bouts are reliable markers of nighttime sleep stability that correlate with CSF ORX levels in a dose-dependent manner.AHI=apnea–hypopnea index; BMI=body mass index; EDS=excessive daytime sleepiness; ICSD-3=International Classification of Sleep Disorders, 3rd ed; IH=idiopathic hypersomnia; MSLT=multiple sleep latency test; NREM=non-REM; NT1=narcolepsy type 1; NT2=narcolepsy type 2; ORX=orexin; PLMS=periodic leg movements during sleep; PSG=polysomnography ER -