TY - T1的抑郁和自杀念头在治疗和治疗嗜睡症JF -神经学乔-神经病学SP - e2755 LP - - 10.1212 / WNL e2768做。首页0000000000010737六世- 95 - 20 AU -露西Barateau盟里吉斯·洛佩兹盟Sofiene Chenini AU -卡罗尔Pesenti盟安娜劳拉Rassu AU - Isabelle Jaussent盟Yves Dauvilliers Y1 - 2020/11/17 UR - //www.ez-admanager.com/content/95/20/e2755.abstract N2 首页-目标评估抑郁症状的频率和决定因素和自杀的念头与嗜睡症成人1型(NT1)和控制,以及更改后NT1管理和主要抑郁发作的危险因素(身边)(SR)的NT1和自杀的风险。方法二百九十七例NT1(年龄39±17年,172无毒)和346名对照(38±16岁)进行了全面的临床评估,包括贝克抑郁Inventory-II self-questionnaire (BDI-II), 1项自杀的想法。一百零一无毒NT1患者完成了第二次BDI-II治疗期间。162年患者NT1,面对面的迷你国际神经精神采访进行正式诊断当前身边和SR.Results BDI-II NT1患者总分数高于在未经处理的控制和治疗的病人。中度到重度的患者BDI-II分数(24.9%)是受教育程度较低,更频繁的肥胖,并且更严重的嗜睡症症状,更自主障碍,贫穷的生活质量。结果不变的模型调整NT1药物摄入量。自杀的念头比管控更频繁的在未经治疗的患者(22.7% vs 12.4%)。患者自杀的想法更容易被男性和更严重的嗜睡症的症状。嗜睡症管理后,BDI-II总分和自杀的念头减少。身边被诊断出在老29(18.1%)和27例(16.9%)患者。Conclusions Depression, depressive symptoms, suicidal thoughts, and SR were frequent in patients with NT1, especially those without treatment, and were associated with NT1 severity. Depressive symptoms and suicidal thoughts improved after NT1 management.BDI=Beck Depression Inventory; CI=confidence interval; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; EDS=excessive daytime sleepiness; EQ-5D=European Quality of Life 5-dimensions; ESS=Epworth Sleepiness Scale; ISI=Insomnia Severity Index; MINI=Mini International Neuropsychiatric Interview; MSLT=Multiple Sleep Latency Test; NSS=Narcolepsy Severity Scale; NT1=narcolepsy type 1; OR=odds ratio; ORX=orexin; PSG=polysomnography; SCOPA-AUT=Scales for Outcomes in Parkinson's Disease–autonomic dysfunction; SOREM=sleep-onset REM period ER -