% 0期刊文章% Alejandra Vasquez尼古拉斯·s .异常终止%码头Gainza-Lein % %一个Marta Amengual-Gual %安妮·安德森% Ravindra Arya %一个j . Nicholas Brenton %一个凯文·查普曼杰西卡·l·卡彭特% %大法官威廉克拉克%一个拉奎尔Farias-Moeller % D盖拉德%一个约书亚·l·戈尔茨坦格劳瑟特蕾西% %霍华德·p·Goodkin %一个库什Kapur Rejean m . Guerriero % %一个Yi-Chen赖%此举l·麦克唐纳%穆罕默德A .米卡提%林赛A·摩根%爱德华j . Novotny %一个亚当·p·Ostendorf %埃里克·T·佩恩胡安Piantino %卡特里娜Peariso % %詹姆斯·j·里维耶洛% Kumar Sannagowdara %一个罗伯特·c·塔斯克%德米特里•Tchapyjnikov %亚历克西斯Topjian % s·温赖特标志%一个安格斯威尔福格% Korwyn威廉姆斯% Tobias Loddenkemper %代表小儿癫痫持续状态研究集团(pSERG) % T一线药物剂量在儿童难治性癫痫持续状态% D R 10.1212 / WNL 2020%。0000000000010828 % J首页神经病学% P e2683-e2696 % V 95% N 19% X目的确定低苯二氮的相关因素(BZD)难治性癫痫持续状态患者的剂量(交易所)和评估在发作停止BZD治疗变异性的影响。方法这是一个回顾性研究与前瞻性收集的数据的惊厥的患儿交易所承认2011年6月至2019年1月。我们分析了初始和总BZD剂量10分钟内开始治疗。我们用逻辑回归模型来评估预测低BZD剂量和多变量Cox回归分析评估的影响低剂量BZD发作停止的时候了。结果包括289例(男性55.7%)平均年龄为4.3(1.3 - -9.5)年。BZDs在278年最初的药物(96.2%)。其中,161名患者(57.9%)接受了较低的初始剂量。低初始BZD剂量发生在心脏按压(57 106;53.8%)和住院(104 172;60.5%)的设置。一百零三名患者(37.1%)接受低总BZD剂量。男性(比值比(或)2,95%可信区间[CI] 1.18 - -3.49; p = 0.012), older age (OR 1.1, 95% CI 1.05–1.17; p < 0.001), no prior diagnosis of epilepsy (OR 2.1, 95% CI 1.23–3.69; p = 0.008), and delayed BZD treatment (OR 2.2, 95% CI 1.24–3.94; p = 0.007) were associated with low total BZD dose. Patients who received low total BZD dosing were less likely to achieve seizure cessation (hazard ratio 0.7, 95% CI 0.57–0.95).Conclusion BZD doses were lower than recommended in both out-of-hospital and in-hospital settings. Factors associated with low total BZD dose included male sex, older age, no prior epilepsy diagnosis, and delayed BZD treatment. Low total BZD dosing was associated with decreased likelihood of Seizure cessation.Classification of evidence This study provides Class III evidence that patients with RSE who present with male sex, older age, no prior diagnosis of epilepsy, and delayed BZD treatment are more likely to receive low total BZD doses. This study provides Class III evidence that in pediatric RSE low total BZD dose decreases the likelihood of seizure cessation.ASM=antiseizure medication; BZD=benzodiazepine; CI=confidence interval; DZP=diazepam; ESETT=Established Status Epilepticus Treatment Trial; HR=hazard ratio; ICU=intensive care unit; IM=intramuscular; LZP=lorazepam; MDZ=midazolam; OR=odds ratio; PR=per rectum; pSERG=Pediatric Status Epilepticus Research Group; p25–p75=interquartile range; RSE=refractory SE; SE=status epilepticus %U //www.ez-admanager.com/content/neurology/95/19/e2683.full.pdf