TY -的T1 - Limbic-predominant老年性TDP-43脑病,ADNC病理学、老化和认知下降JF -神经学乔-神经病学SP - e1951 LP - e1962做- 10.1212 / WNL。首页0000000000010454六世- 95 - 14盟Lei Yu - Alifiya·卡帕西的文章盟盟-帕特里夏·a·博伊尔盟丽莎·l·巴恩斯AU -大卫·a·班尼特盟朱莉·a·施耐德Y1 - 2020/10/06 UR - //www.ez-admanager.com/content/95/14/e1951.abstract N2 -客观检查3病理组织的影响,首页纯limbic-predominant与年龄相关的交互响应dna结合蛋白43脑病(已故)neuropathologic变化(NC),纯粹的阿尔茨海默病neuropathologic变化(ADNC)和混合ADNC LATE-NC,老年认知能力下降。方法的数据来自1356名社区老年人认知测试和系统完成详细的年度neuropathologic考试尸检确定LATE-NC, ADNC和其他与年龄相关的疾病。人分为(0)一群没有病理诊断延迟或ADNC (n = 378), (1) LATE-NC没有ADNC (n = 91), (2) ADNC没有LATE-NC (n = 535)、和(3)混合ADNC LATE-NC (n = 352)。我们利用混合效应模型分析联想集团,下降的速度在全球认知和5岁认知领域,然后检查是否修改关联。结果相比没有LATE-NC或ADNC,那些纯LATE-NC有更快的全球认知下降(p = 0.025)和情景记忆(p = 0.002);然而,与纯ADNC的人相比,那些纯LATE-NC显示较慢的下降。那些与混合ADNC LATE-NC相比下降最快的单独与病理。≥90岁的人与混合ADNC LATE-NC认知能力下降缓慢,相比≤89岁。结论人用纯LATE-NC遵循慢的轨迹与纯ADNC相比。那些混合/ ADNC末有一个陡峭的下降比个人独自与病理。此外,年龄可能修改病理学对认知能力下降的影响。这些发现对于生物标记的发展和预后具有重要意义对老年认知能力下降。Classification of evidence This study provides Class I evidence that LATE-NC and Alzheimer disease pathologic changes are associated with different trajectories of late-life cognitive decline.AD=Alzheimer disease; CAA=cerebral amyloid angiopathy; CERAD=Consortium to Establish a Registry for Alzheimer’s Disease; CI=confidence interval; FTLD=frontotemporal lobar degeneration; HS=hippocampal sclerosis; LATE=limbic-predominant age-related TDP-43 encephalopathy; MAP=Rush Memory and Aging Project; MARS=Minority Aging Research Study; NC=neuropathologic changes; NIA=National Institute on Aging; ROS=Religious Orders Study; TDP-43=transactive response DNA-binding protein 43 ER -