TY -的T1 -未来的和谐多中心DTI研究脑白质变性ALS JF -神经学乔-神经病学SP - e943 LP - - 10.1212 / WNL e952做。首页0000000000010235六世- 95 - 8 AU - Sanjay卡尔拉盟汉斯穆勒AU -阿卜杜拉Ishaque盟Lorne Zinman AU -劳伦斯Korngut AU -安吉拉其全称盟基督教比尤利AU -理查德如今非盟-西蒙·j·格雷厄姆盟Jan Kassubek Y1 - 2020/08/25 UR - //www.ez-admanager.com/content/95/8/e943.abstract N2 -目的评价进步白质(WM)变性肌萎缩性脊髓侧索硬化症(ALS)。首页方法六十六名ALS患者和健康对照组43参与了一项前瞻性纵向,多中心研究在加拿大ALS神经影像财团(CALSNIC)。参与者进行了协调神经成像协议在4中心,包括扩散张量成像(DTI) WM完整性的评估。三个访问伴随着临床评估残疾(ALS功能评定量表——[ALSFRS-R])和上运动神经元(学院)的功能。Voxel-wise整个大脑和定量tract-wise DTI评估是在基线和纵向。网站方差校正合并数据从健康对照组和健康的志愿者进行了DTI在每个中心协议。结果ALS患者平均分数各向异性(FA)的逐步下降,尤其是皮质脊髓束(CST)和额叶。Tract-wise分析显示减少FA春秋国旅,corticopontine / corticorubral束和层次。中科FA与学院相关功能,额叶FA与ALSFRS-R得分。逐步下降,尤其是春秋国旅FA与ALSFRS-R得分下降和恶化相关学院的迹象。快与慢的患者进展有一个更大的减少FA CST和上额叶。Conclusions Progressive WM degeneration in ALS is most prominent in the CST and frontal lobes and, to a lesser degree, in the corticopontine/corticorubral tracts and corticostriatal pathways. With the use of a harmonized imaging protocol and incorporation of analytic methods to address site-related variances, this study is an important milestone toward developing DTI biomarkers for cerebral degeneration in ALS.ClinicalTrials.gov identifier NCT02405182.ALS=amyotrophic lateral sclerosis; ALSFRS-R=ALS Functional Rating Scale–Revised; CALSNIC=Canadian ALS Neuroimaging Consortium; CST=corticospinal tract; DTI=diffusion tensor imaging; FA=fractional anisotropy; FDR=false discovery rate; TFAS=tract-wise FA statistics; TOI=tract of interest; UMN=upper motor neuron; WBSS=whole brain–based spatial statistics; WM=white matter ER -