TY -的T1 -晚贡献重复性的影响和创伤性脑损伤的抑郁症状和认知JF -神经学乔-神经病学SP - e793 LP - e804做- 10.1212 / WNL。首页0000000000010040六世- 95 - 7非盟- Michael l . Alosco盟Yorghos Tripodis AU -扎卡里·h·Baucom盟杰西Mez盟Brett马丁-托尔·d·斯坦盟盟-奥利维亚Haller AU -香农Conneely盟-迈克尔McClean AU -瑞秋Nosheny盟-斯科特Mackin AU -安·c·麦基盟——迈克尔·w·维纳盟——罗伯特·斯特恩Y1 - 2020/08/18 UR - //www.ez-admanager.com/content/95/7/e793.abstract N2 -客观测试假设重复性的影响(这),像那些从接触体育游戏和创伤性脑损伤(TBI)有长期神经和认知的后果,我们比较中年和老年人参与者报告开展的首页历史和/或与那些没有这段历史的创伤性脑损伤的措施抑郁症和认知。本横断式研究方法包括13323人(平均年龄61.95;72.5%女性)的大脑健康注册完成在线评估,包括俄亥俄州立大学创伤性脑损伤的识别方法,老年抑郁量表(GDS-15), CogState短暂的电池和lumo实验室神经认知性能测试。逆propensity-weighted线性回归占年龄,性别,种族,教育测试RHI创伤性脑损伤的影响而non-RHI /创伤性脑损伤组。结果共有725名参与者报告开展的风险(主要是接触体育游戏和滥用)和7277年报道创伤性脑损伤与意识丧失(n = 2604 (LOC))。奥镁(β,1.24;95%可信区间,0.36 - -2.12),创伤性脑损伤没有LOC(β0.43;95%置信区间,0.31 - -0.54),和创伤性脑损伤的LOC(β0.75;95%可信区间,0.59 - -0.91)与高GDS-15分数。在创伤性脑损伤的LOC最神经心理协会、创伤性脑损伤没有LOC有负面影响CogState识别(β0.004;95%可信区间,0.001 - -0.01)和CogState测试(β0.004; 95% CI, 0.0002–0.01). RHI predicted worse CogState One Back Test scores (β, 0.02; 95% CI, −0.01 to 0.05). There were RHI × TBI interaction effects on several neuropsychological subtests, and participants who had a history of both RHI and TBI with LOC had the greatest depression symptoms and worse cognition.Conclusions RHI and TBI independently contributed to worse mid- to later-life neuropsychiatric and cognitive functioning.AD=Alzheimer disease; ADRD=Alzheimer disease–related dementias; BHR=Brain Health Registry; CBB=CogState Brief Battery; CI=confidence interval; DET=detection; FMS=Forward Memory Span; GDS-15=15-item Geriatric Depression Scale; GNG=Go/No-Go; IDN=identification; LOC=loss of consciousness; NCPT=NeuroCognitive Performance Tests; OCL=one card learning; ONB=one-back test; OSU TBI-ID=Ohio State University TBI Identification Method; RHI=repetitive head impact; RMS=Reverse Memory Span; TBI=traumatic brain injury; TMTB=Trail-Making Test Part B; UCSF=University of California, San Francisco ER -