TY - T1的多巴胺能系统中断后创伤性脑损伤(S9.008) JF -神经学乔-神经学六世- 88 - 16补充SP - S9.008盟彼得·詹金斯盟——莎拉·德·西摩尼盟——尼尔·伯克AU -詹姆首页斯·科尔盟大卫夏普Y1 - 2017/04/18 UR - //www.ez-admanager.com/content/88/16_Supplement/S9.008.abstract N2 -目的:调查:1)创伤性脑损伤(TBI)减少纹状体多巴胺转运体(DAT)水平;2)创伤性脑损伤导致结构性变化的黑质和/或黑束;3)DAT水平后创伤性脑损伤与黑质或黑呼吸道损伤;4)DAT水平与行为的冷漠和/或速度的处理措施。背景:持续的创伤性脑损伤后认知障碍是常见的。创伤性脑损伤的异构特性的基础意味着认知功能障碍可能是单一性。动物和人类的研究表明多巴胺能中断后创伤性脑损伤。然而,中断的原因尚不清楚,可能与多巴胺核损伤或提升预测。设计/方法:32中度/重度创伤性脑损伤患者持续的认知问题和15名健康对照组有ioflupane (123 i) SPECT扫描(DaTscan),核磁共振和全面的神经心理学评估。纹状体的DAT水平测定。MRI是用来计算黑质量和黑束扩散指标。结果:定量评估显示,创伤性脑损伤病人DAT水平降低。 Patients had substantia nigra atrophy, as well as increased mean diffusivity in the nigrostriatal tract. There was a significant relationship between (1) DAT levels and substantia nigra volumes in patients and (2) mean diffusivity in the nigrostriatal tract and anterior striatal DAT levels. DAT levels showed a significant relationship with apathy measures but not speed of processing.Conclusions: A proportion of TBI patients with persistent cognitive problems have reduced striatal DAT levels implying a disruption to their dopaminergic system. DAT levels are correlated with structural changes in the substantia nigra and nigrostriatal tract. This supports a causal relationship between damage to these regions by TBI and functional dopaminergic dysfunction. Reduced DAT levels also relate to apathy. Dopaminergic therapies may therefore benefit those patients with evidence of disruption to their dopaminergic systems.Study Supported by:Guarantors of BrainNIHRDisclosure: Dr. Jenkins has nothing to disclose. Dr. De Simoni has nothing to disclose. Dr. Bourke has nothing to disclose. Dr. Cole has nothing to disclose. Dr. Sharp has nothing to disclose. ER -