% 0期刊文章%罗西尼。D . Dobkin %的莎拉·l·曼% Alejandro Interian迈克尔·A·加拉% % Matthew Menza Kailyn m .罗德里格斯% % T在线认知行为疗法对帕金森病抑郁% B随机对照试验% D R 10.1212 / WNL 2020%。0000000000009292 % J首页神经病学% P e1764-e1773 % V 94% N X目的确定,16%患者的抑郁症和帕金森病(PD),在线认知行为治疗(T-CBT)缓解抑郁症状大大超过常规治疗(τ),我们进行了一项随机对照试验评估的有效性10-session T-CBT干预抑郁症在PD,而τ。方法七十二人PD (PWP)随机T-CBT +τ或τ。T-CBT根据工务计划的独特需求提供每周3个月、6个月随访期间每月。认知行为治疗有针对性的消极的想法(例如,“我没有控制”;“我无能为力”)和行为(例如,不合群,过度担心)。工务计划也训练保健合作伙伴帮助实践健康习惯。盲目的评级机构评估结果在基线,midtreatment,治疗结束,1和6个月治疗。意图治疗分析。结果T-CBT优于τ在所有抑郁,焦虑,和生活质量的措施。主要结果(汉密尔顿抑郁量表评分)明显改善T-CBTτ相比,治疗结束。 Mean improvement from baseline was 6.53 points for T-CBT and −0.27 points for TAU (p < 0.0001); gains persisted over 6-month follow-up (p < 0.0001). Improvements were moderated by a reduction in negative thoughts in the T-CBT group only, reflecting treatment target engagement.Conclusions T-CBT may be an effective depression intervention that addresses a significant unmet PD treatment need and bypasses access barriers to multidisciplinary, evidence-based care.Clinicaltrials.gov identifier NCT02505737.Classification of evidence This study provides Class I evidence that for patients with depression and PD, T-CBT significantly alleviated depressive symptoms compared to usual care.ARR=absolute risk reduction; BDI=Beck Depression Inventory; CBT=cognitive-behavioral therapy; CGI-I=Clinical Global Impression Improvement Scale; CI=confidence interval; dPD=depression in Parkinson disease; DSM-5=Diagnostic and Statistical Manual of Mental Disorders, 5th edition; HAM-A=Hamilton Anxiety Rating Scale; HAM-D=Hamilton Depression Rating Scale; MCS=mental health composite score; MDD=major depressive disorder; NNT=number needed to treat; PWP=people with Parkinson disease; PD=Parkinson disease; RCT=randomized controlled trial; SF-36=Short Form–36; T-CBT=telephone-based cognitive-behavioral therapy; TAU=treatment as usual %U //www.ez-admanager.com/content/neurology/94/16/e1764.full.pdf