% 0期刊文章% Elisa Canu % Federica Agosta %一个Michela Leocadi %一个Veronica Castelnovo Davide Calderaro % % Paola Caroppo %一个萨拉Prioni %卢西奥Tremolizzo % Ildebrando Appollonio % Paola Valsasina %马西莫菲利皮主持% T大脑功能连通性与右颞变性(1521)% D J神经病学2020% % P V 94% 1521% N % X 15补充目的:本研究的目的是评估功能连通性(FC)模式与右颞额颞叶痴呆的变体(rtvFTD)相比,正常老化。首页背景:rtvFTD,通常命名为“正确的语义痴呆”,经常挑战的临床分类,因为它并不完全符合FTD的行为变异的标准和原发性进行性失语的语义变体。设计/方法:我们招收6最近患者临床和成像诊断rtvFTD和20岁,sex-matched健康对照组(HC)。神经心理评估和静息状态功能磁共振成像(RS-fMRI)从所有参与者获得。RS FC网络被确定使用独立分量分析(礼物工具箱,SPM12)。为每个网络感兴趣的(默认模式,左派和右派frontoparietal红外系统,突出,fronto-striatal,前颞和小脑网络,主要和联想视觉网络,以及感觉网络),进行组间比较。结果:在神经心理评估,所有患者行为改变,在命名和语言理解困难,抽象推理,情感和著名的面孔识别。HC相比,rtvFTD病人显示增加连接正确的前颞中梭状回网络,和正确的下颞叶皮层(大脑区域20)在红外系统的权利。结论:本研究表明,rtvFTD患者的特点是改变了FC网络纯额和语言以外的电路,主要针对关键地区参与高层视觉处理。如果观察到增加FC是代偿机制或者说是反映了下面病理过程仍然需要确定。总之,RS-fMRI是一个基本的工具允许改善这种罕见的区别,研究条件和其他变异的FTD仍然不佳。披露:Canu博士没有披露。Agosta博士已经收到个人赔偿咨询、担任科学顾问委员会说,或其他活动Idec, Novartis.Dr。Leocadi没有披露。 Dr. Calderaro has nothing to disclose. Dr. Castelnovo has nothing to disclose. Dr. Caroppo has nothing to disclose. Dr. Prioni has nothing to disclose. Dr. Lucio has nothing to disclose. Dr. Appollonio has nothing to disclose. Dr. Valsasina has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with speakers’ honoraria from ExceMed. Dr. Filippi has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in an editorial capacity for Journal of Neurology. Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche,Teva Pharmaceutical Industries. %U