PT -期刊文章盟艾玛·福斯特AU - Charles b . Malpas盟林嘉欣你们盟-本杰明·约翰斯通AU -帕特里克·w·卡尼AU -丹尼斯Velakoulis AU -特伦斯j . O ' brien盟帕特里克关颖珊TI -抗癫痫药物不是独立- 10.1212 / WNL与认知功能障碍相关的援助。0000000000009061 DP - 2020年3月10 TA -神经病首页学PG - e1051 e1061 VI - 94 IP - 10 4099 - //www.ez-admanager.com/content/94/10/e1051.short 4100 - //www.ez-admanager.com/content/94/10/e1051.full所以Neurology2020 3月10;94 AB -客观测试假设个人抗癫痫药物(aed)不与认知障碍以外的其他临床相关因素有关,我们进行了横断面研究的病人承认一个住院video-EEG监控单元。方法前瞻性的癫痫患者住院专家承认,计划在2009年和2016年之间。评估包括客观认知功能、生活质量的主观认知功能量表”,并为焦虑和抑郁症状的调查问卷。贝叶斯模型平均预测认知功能。贝叶斯模型选择方法调查个人aed对认知的影响。传统的频率论的分析也执行。结果共有331例患者符合入选标准。平均年龄为39.3岁,61.9%的患者为女性。总共有45.0%的病人被规定AED复方用药,25.1% AED单药治疗,29.9%没有AED。年龄、发作频率和伴随的诊断癫痫和精神性的nonepileptic发作是客观认知功能的预测。 Depression, anxiety, and seizure frequency were predictors of subjective cognitive function. Individual AEDs were not independently associated with impaired cognitive function beyond other clinically relevant variables.Conclusions This study found that no AED was independently associated with cognitive dysfunction. Significant determinants of objective and subjective cognitive dysfunction included seizure frequency and depression, respectively. These findings suggest that optimizing therapy to prevent seizures is not likely to occur at the expense of cognitive function.AED=antiepileptic drug; BF=Bayes factor; BMA=Bayesian model averaging; GLM=general linear model; HADS=Hospital Anxiety and Depression Scale; NUCOG=Neuropsychiatry Unit Cognitive Assessment Tool; PCA=principal components analysis; PIP=posterior inclusion probability; PNES=psychogenic nonepileptic seizures; QOLIE=Quality of Life in Epilepsy inventory; VEM=video-EEG monitoring