RT期刊文章SR电子T1 TDP和海马硬化的贡献海马体积亏损older-old人乔摩根富林明神经病学神经病学FD Lippincott Williams &威尔金斯SP e142 OP e152 10.1212 / WNL。首页94签证官0000000000008679是2 A1 Lei Yu A1帕特里夏·a·博伊尔A1 Robert j . Dawe A1大卫·a·贝内特A1 Konstantinos Arfanakis A1朱莉·a·施耐德年2020 UL //www.ez-admanager.com/content/94/2/e142.abst首页ract AB目的探讨阿尔茨海默病(AD)的贡献vs non-AD神经病理学海马萎缩。方法研究宗教团体和拉什记忆和衰老项目是衰老的临床病理的群组研究。目前的研究包括547名参与者进行大脑解剖和后期海马体积测量到11月1日,2018年。海马体积测量通过一个3 d与后期MRI的应用到海马结构。神经病理学测量通过统一的结构化的评估。线性回归分析估计的方差的比例海马体积归因于广告和non-AD神经病理学。结果死亡的平均年龄是90岁,海马体积和平均为2.1毫升。广告,交互响应dna结合蛋白43 (TDP),海马硬化(HS)和动脉粥样硬化相关的海马体积。人口统计和半球总量控制后,7.0%的方差(引导95%可信区间(CI) 4.3% - -10.5%)的海马体积可归因于AD病理。TDP /海关解释了另外的4.5% (95% CI 2.2% - -7.6%)。个体与老年痴呆(n = 232)、3.1%(95%可信区间0.6% - -7.7%)的方差可归因于广告病理学,TDP /海关解释了一个额外的6.1% (95% CI 2.2% - -11.6%)。 Among those without Alzheimer dementia (n = 307), 3.2% (95% CI 0.9%–7.3%) of the variance was attributable to AD pathology, and TDP/HS explained an additional 1.1%, which did not reach statistical significance. Lewy bodies and vascular diseases had modest contribution to the variance of hippocampal volume.Conclusions Both AD and TDP/HS contribute to hippocampal volume loss in older-old persons, with TDP/HS more strongly associated with hippocampal volume than AD in Alzheimer dementia.AD=Alzheimer disease; CERAD=Consortium to Establish a Registry for Alzheimer's Disease; CI=confidence interval; HS=hippocampal sclerosis; NIA=National Institute on Aging; PHF=paired helical filament; ROSMAP=Religious Orders Study and Rush Memory and Aging Project; TDP=transactive response DNA-binding protein 43

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