RT期刊文章SR电子T1脑脊液动力学障碍摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e2237 OP e2246首页 10.1212 / WNL。93签证官0000000000008616是24 A1乔纳森Graff-Radford A1 Jeffrey l . Gunter A1大卫·t·琼斯A1 Scott a Przybelski A1克里斯托弗·g·施瓦兹A1约翰·休斯顿三世A1 Val劳A1本杰明·d·长老A1玛丽m . Machulda A1纳撒尼尔·b·甘特A1罗纳德·c·彼得森A1 Kejal Kantarci A1 Prashanthi Vemuri A1米歇尔·m·Mielke A1 David s . Knopman A1尼尔r . Graff-Radford A1克利福德·r·杰克,小岁2019 UL //www.ez-admanager.com/content/93/24/e2237.abstract AB客观确定的频率high-convexity紧沟(hct)以人群为基础的样本,是否存在hct和相关特性影响参与者的认知状况和新首页的Alzheimer-biomarker框架内的分类。方法分析684名参与者≥50岁进入衰老的潜在人群梅奥诊所研究,并进行了结构的MRI、淀粉PET成像和τPET成像。一个完全自动化的机器学习算法开发以前的房子是用来检测hct的神经影像学特征。PET和MRI措施的基础上,参与者划分(−)正常或异常(+)淀粉样蛋白,正常(T−)或异常(T +)τ,和正常(N−)或异常(N +)神经退化。电池的神经心理学评估特定领域和全球认知得分。步态速度也被评估。调整了年龄和性别分析。结果684名参与者,45(6.6%)与hct根据自动分类算法。hct患者年龄超过患者没有hct(意思是(SD) 78.0(8.3)和71.9(10.8)年;p < 0.001)。 More were cognitively impaired after age and sex adjustment (27% vs 9%; p = 0.005). Amyloid PET status was similar with and without HCTS, but tau PET standard uptake value ratio (SUVR) was lower for those with HCTS after age and sex adjustment (p < 0.001). Despite a lower tau SUVR, patients with HCTS had lower Alzheimer disease (AD) signature cortical thickness. With the amyloid-tau-neurodegeneration framework, HCTS was overrepresented in the T−(N)+ group, regardless of amyloid status.Conclusion The HCTS pattern represents a definable subgroup of non-AD pathophysiology (i.e., T−[N]+) that is associated with cognitive impairment. HCTS may confound clinical and biomarker interpretation in AD clinical trials.Aβ42=β-amyloid42; AD=Alzheimer disease; AT(N)=amyloid-tau-neurodegeneration; CDD=CSF dynamics disorder; DESH=disproportionately enlarged subarachnoid space hydrocephalus; FLAIR=and fluid-attenuated inversion recovery; HCTS=high-convexity tight sulci; MCALT=Mayo Clinic Adult Lifespan Template; MCSA=Mayo Clinic Study of Aging; MPRAGE=magnetization-prepared rapid gradient-echo; NPH=normal-pressure hydrocephalus; PiB=Pittsburgh compound B; SUVR=standard uptake value ratio