TY -的T1 -脑脊液动力学障碍JF -神经学乔-神经病学SP - e2237 LP - - 10.1212 / W首页NL e2246做。0000000000008616六世- 93 - 24盟-乔纳森Graff-Radford盟Jeffrey l .甘特盟——大卫·t·琼斯AU -斯科特·a·Przybelski盟克里斯托弗·g·施瓦兹非盟-约翰·休斯顿三世AU - Val劳盟-本杰明·d·长老盟——玛丽·m·Machulda盟——纳撒尼尔·b·甘特盟-罗纳德·c·彼得森盟Kejal Kantarci AU - Prashanthi Vemuri AU -米歇尔·m·Mielke盟David s . Knopman AU -尼尔r . Graff-Radford盟克利福德·r·杰克,小Y1 - 2019/12/10 UR - //www.ez-admanager.com/content/93/24/e2237.abstract N2 -客观确定的频率high-convexity紧沟(hct)以人群为基础的样本,是否存在hct和相关特性影响参与者的认知状况和新的Alzheimer-biomarker框架内的分类。首页方法分析684名参与者≥50岁进入衰老的潜在人群梅奥诊所研究,并进行了结构的MRI、淀粉PET成像和τPET成像。一个完全自动化的机器学习算法开发以前的房子是用来检测hct的神经影像学特征。PET和MRI措施的基础上,参与者划分(−)正常或异常(+)淀粉样蛋白,正常(T−)或异常(T +)τ,和正常(N−)或异常(N +)神经退化。电池的神经心理学评估特定领域和全球认知得分。步态速度也被评估。调整了年龄和性别分析。结果684名参与者,45(6.6%)与hct根据自动分类算法。hct患者年龄超过患者没有hct(意思是(SD) 78.0(8.3)和71.9(10.8)年;p & lt; 0.001). More were cognitively impaired after age and sex adjustment (27% vs 9%; p = 0.005). Amyloid PET status was similar with and without HCTS, but tau PET standard uptake value ratio (SUVR) was lower for those with HCTS after age and sex adjustment (p < 0.001). Despite a lower tau SUVR, patients with HCTS had lower Alzheimer disease (AD) signature cortical thickness. With the amyloid-tau-neurodegeneration framework, HCTS was overrepresented in the T−(N)+ group, regardless of amyloid status.Conclusion The HCTS pattern represents a definable subgroup of non-AD pathophysiology (i.e., T−[N]+) that is associated with cognitive impairment. HCTS may confound clinical and biomarker interpretation in AD clinical trials.Aβ42=β-amyloid42; AD=Alzheimer disease; AT(N)=amyloid-tau-neurodegeneration; CDD=CSF dynamics disorder; DESH=disproportionately enlarged subarachnoid space hydrocephalus; FLAIR=and fluid-attenuated inversion recovery; HCTS=high-convexity tight sulci; MCALT=Mayo Clinic Adult Lifespan Template; MCSA=Mayo Clinic Study of Aging; MPRAGE=magnetization-prepared rapid gradient-echo; NPH=normal-pressure hydrocephalus; PiB=Pittsburgh compound B; SUVR=standard uptake value ratio ER -