TY -的T1 - < em > APOE < / em >ε4,白质hyperintensities,阿尔茨海默和路易体痴呆摩根富林明和认知——神经学乔-神经病学SP - e1807 LP - - 10.1212 / WNL e1819首页做。0000000000008377六世- 93 - 19盟Saira赛义德Mirza AU -乌斯曼赛义德盟骑士乔盟-乔尔·拉米雷斯盟-唐纳德·t·斯特斯AU -茱莉亚基思盟Di Yu -肖恩·m·内斯特盟盟-沃尔特Swardfager盟Ekaterina Rogaeva AU -彼得·圣乔治Hyslop AU -桑德拉·e·黑盟-马里奥Masellis AU -阿尔茨海默病的神经影像学Y1 - 2019/11/05 UR - //www.ez-admanager.com/content/93/19/e1807.abstract N2 -目的确定APOEε4影响白质hyperintensities之间的关系(负责人)和认知障碍在阿尔茨海默病(AD)和路易体痴呆(下文)。首页方法共有289名患者(广告= 239;下文= 50)进行了MRI体积,神经心理测试和APOEε4基因分型。研究负责人总量被量化。神经心理学测试成绩进行验证性因子分析来识别认知领域包括关注/执行功能、学习/记忆和语言,因子得分为每个域计算每个参与者。测试负责人之间的相互作用和APOEε4后完整的样品,我们测试了协会的负责人使用线性回归模型与因子得分APOEε4运营商(n = 167)和非(n = 122)。我们假设体积更大的负责人会与糟糕认知APOEε4运营商更强烈。患者发现复制198年广告从阿尔茨海默病的神经影像学(ADNI-I),和两样本meta-analyzed估计。观察结果显著交互作用研究负责人和APOEε4之间的语言,而不是内存或执行功能。在APOEε4携带者和非独立的分析表明,更大的研究负责人成交关注/执行功能较差,学习/记忆和语言的APOEε4运营商。ADNI-I、大负责人负担与糟糕的注意/执行功能和语言APOEε4运营商。 No significant associations were observed in noncarriers. Meta-analyses showed that greater WMH volume was associated with worse performance on all cognitive domains in APOE ε4 carriers only.Conclusion APOE ε4 may influence the association between WMH and cognitive performance in AD and DLB.Aβ=β-amyloid; AD=Alzheimer disease; ADNI-I=Alzheimer's Disease Neuroimaging Initiative Phase I; ANOVA=analysis of variance; BDS=backward digit span; BNT=Boston Naming Test; CAA=cerebral amyloid angiopathy; CFA=Confirmatory Factor Analysis; CFI=comparative fit index; CI=confidence interval; CVLT=California Verbal Learning Test; DLB=dementia with Lewy bodies; DSST=Digit Symbol Substitution Task; FDS=forward digit span; MMSE=Mini-Mental State Examination; PD=proton density; PF-FAS=Controlled Oral Word Association task–Phonemic Fluency; RAVLT=Rey Auditory Verbal Learning Test; RMSEA=root mean square error of approximation; SDS=Sunnybrook Dementia Study; SF=Semantic Fluency; SRMR=standardized root mean square; SVD=small vessel disease; TIV=total intracranial volume; WCST=Wisconsin Card Sorting Test; WMH=white matter hyperintensities; WMS=Wechsler Memory Scale ER -