@article {Mirzae1807作者= {Saira赛义德米尔扎和乌斯曼赛义德乔骑士和乔尔·拉米雷斯唐纳德·t·斯特斯和茱莉亚基斯和肖恩·m·内斯特Di Yu和沃尔特Swardfager Ekaterina Rogaeva和彼得·圣乔治Hyslop桑德拉·e·黑和马里奥Masellis {\ textquoteright}年代老年痴呆症神经影像倡议},title = {APOEε4、白质hyperintensities和认知在老年痴呆症和路易体痴呆},体积={93}={19},页面= {e1807——e1819} = {2019}, doi = {10.1212 / WNL。出版商0000000000008377}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的确定APOEε4影响白质hyperintensities之间的关系(负责人首页)和认知障碍在阿尔茨海默病(AD)和路易体痴呆(下文)。方法共有289名患者(广告= 239;下文= 50)进行了MRI体积,神经心理测试和APOEε4基因分型。研究负责人总量被量化。神经心理学测试成绩进行验证性因子分析来识别认知领域包括关注/执行功能、学习/记忆和语言,因子得分为每个域计算每个参与者。测试负责人之间的相互作用和APOEε4后完整的样品,我们测试了协会的负责人使用线性回归模型与因子得分APOEε4运营商(n = 167)和非(n = 122)。我们假设体积更大的负责人会与糟糕认知APOEε4运营商更强烈。发现复制在198 AD患者{\ textquoteright}年代老年痴呆症神经影像倡议(ADNI-I),和两样本meta-analyzed估计。观察结果显著交互作用研究负责人和APOEε4之间的语言,而不是内存或执行功能。在APOEε4携带者和非独立的分析表明,更大的研究负责人成交关注/执行功能较差,学习/记忆和语言的APOEε4运营商。ADNI-I、大负责人负担与糟糕的注意/执行功能和语言APOEε4运营商。没有观察到非显著的关联。 Meta-analyses showed that greater WMH volume was associated with worse performance on all cognitive domains in APOE ε4 carriers only.Conclusion APOE ε4 may influence the association between WMH and cognitive performance in AD and DLB.Aβ=β-amyloid; AD=Alzheimer disease; ADNI-I=Alzheimer{\textquoteright}s Disease Neuroimaging Initiative Phase I; ANOVA=analysis of variance; BDS=backward digit span; BNT=Boston Naming Test; CAA=cerebral amyloid angiopathy; CFA=Confirmatory Factor Analysis; CFI=comparative fit index; CI=confidence interval; CVLT=California Verbal Learning Test; DLB=dementia with Lewy bodies; DSST=Digit Symbol Substitution Task; FDS=forward digit span; MMSE=Mini-Mental State Examination; PD=proton density; PF-FAS=Controlled Oral Word Association task{\textendash}Phonemic Fluency; RAVLT=Rey Auditory Verbal Learning Test; RMSEA=root mean square error of approximation; SDS=Sunnybrook Dementia Study; SF=Semantic Fluency; SRMR=standardized root mean square; SVD=small vessel disease; TIV=total intracranial volume; WCST=Wisconsin Card Sorting Test; WMH=white matter hyperintensities; WMS=Wechsler Memory Scale}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/93/19/e1807}, eprint = {//www.ez-admanager.com/content/93/19/e1807.full.pdf}, journal = {Neurology} }