TY - T1的冲动控制障碍的帕金森病和RBD JF -神经学乔-神经病学SP - e675 LP - - 10.1212 / WNL e687做。首页0000000000007942六世- 93 - 7非盟-法赫德Baig盟马克·j·凯利盟-迈克尔·a·劳顿盟克劳迪奥·Ruffmann盟-米甲Rolinski盟约翰内斯·c·克莱因AU -托马斯·巴伯盟克里斯汀罗盟- Yoav Ben-Shlomo盟盟该案大卫-米歇尔·t·胡Y1 - 2019/08/13 UR - //www.ez-admanager.com/content/93/7/e675.abstract N2 -客观描述流行,自然历史和风险因素控制冲动行为(学院)在帕金森病(PD)患者中,那些REM睡眠行为障碍(RBD),和控制。首页方法参与者与PD早期诊断(3.5年),那些RBD,控制临床表型和筛查银行独立委员会纵向(问卷的冲动在帕金森病)。ICB-positive个人被邀请半结构式访谈,重复1年后。ICB的严重性评估与帕金森冲动控制规模。多个归责和回归模型来估计银行独立委员会患病率和关联。结果921例PD的基线数据,在18个月,768例和531例,包括在36个月,21%到25%的筛查阳性银行独立委员会在每个访问。采访的银行独立委员会screen-positive个人显示,10%符合正式的标准为冲动控制障碍(ICD),而33%的有亚综合征ICD (ICB症状没有达到ICD)的正式的诊断标准。这些数据结合时通过使用多个归罪,PD-ICB估计的患病率为19.1%(95%置信区间10.1 - -28.2)。在随访,24%的亚综合征病例ICD已经开发了完整的ICD的症状。PD-ICD与多巴胺受体激动剂使用,冷漠的运动并发症,但不是PD-RBD。 ICD prevalence in the RBD group (1%) was similar to that in controls (0.7%).Conclusions ICBs occur in 19.1% of patients with early PD, many persisting or worsening over time. RBD is not associated with increased ICD risk. Psychosocial drivers, including mood and support networks, affect severity.CI=confidence interval; DA=dopamine agonist; DSM-5=Diagnostic and Statistical Manual of Mental Disorders, 5th edition; ICARUS=Impulse Control Disorders and the Association of Neuropsychiatric Symptoms, Cognition and Quality of Life in Parkinson Disease; ICB=impulse control behavior; ICD=impulse control disorder; LEDD=levodopa equivalent daily dose; MDS-UPDRS=Movement Disorder Society–revised Unified Parkinson's Disease Rating Scale; PICS=Parkinson's Impulse-Control Scale; QUIP=Questionnaire for Impulse Control Disorders in Parkinson's Disease; QUIP-S=QUIP Short Form; RBD=REM sleep behavior disorder ER -