% 0期刊文章%尼尔斯·Bergsland Robert Zivadinov % %一个Deepa p . Ramasamy Jesper Hagemeier % %迈克尔·g·德怀尔%一个鲤鱼科尔布费迪南德Schweser % % Bianca Weinstock-Guttman %大卫Hojnacki % T累积gadodiamide管理会导致大脑钆沉积早期% D 2019% R 10.1212 / WNL女士。0000000000007892 % J首页神经病学% P e611-e623 X % V 93% N 6%目标频繁提醒管理造影剂在多发性硬化症(MS)可能会增加信号强度(SI) unenhanced t1加权成像MRI在整个大脑。我们评估终身累积剂量的gadodiamide之间的关系管理和增加SI在齿状核(DN),苍白球(GP)和丘脑患者早期MS.Methods 203 MS患者与基线和随访MRI评估(107)和262岁——sex-matched控制被包含在这回顾,纵向,3 t MRI-reader-blinded研究。患者在基线和疾病持续时间< 2年女士收到专门gadodiamide MRI时间点。如果比(SIR)脑桥和侧脑室脑脊液体积(CSF-LVV)进行评估。协方差分析和相关性分析,调整年龄、性别、和地区感兴趣的体积。结果平均随访时间为55.4个月,提醒造影剂政府的平均数是9.2。患者在随访,49.3%的女士,没有控制显示DN T1 hyperintensity (p < 0.001)。DN的平均先生(p < 0.001)和脑桥GP (p = 0.005), DN的先生的意思是,医生、患者和丘脑CSF-LVV高女士相比,控制(p < 0.001)。与数字有关的DN脑桥是爵士gadodiamide剂量(p < 0.001)。爵士之间没有关联的DN, GP和丘脑和临床和MRI随访结果发现了疾病的严重程度。Conclusions DN, GP, and thalamus gadolinium deposition in early MS is associated with lifetime cumulative gadodiamide administration without clinical or radiologic correlates of more aggressive disease.ANT=advanced normalization tool; CI=confidence interval; CIS=clinically isolated syndrome; CSF-LVV=CSF of lateral ventricle volume; DN=dentate nucleus; FLAIR=fluid-attenuated inversion recovery; FOV=field of view; GBCA=gadolinium-based contrast agents; GM=gray matter; GP=globus pallidus; ICC=intraclass correlation coefficient; LV=lesion volume; MRF=most recent follow-up; MS=multiple sclerosis; ROI=region of interest; RRMS=relapsing-remitting multiple sclerosis; CSI=signal intensity; SIR=signal intensity ratio; TE=echo time; TI=inversion time; TR=repetition time; WI=weighted images; WM=white matter %U //www.ez-admanager.com/content/neurology/93/6/e611.full.pdf