RT期刊文章SR电子T1颞叶癫痫摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e2首页209 OP e2220 10.1212 / WNL。92签证官0000000000007447 19岁A1鲍里斯·c·伯恩哈特A1今天Fadaie A1分钟刘A1 Benoit Caldairou A1史古A1伊丽莎白Jefferies A1乔纳森·斯莫尔伍德A1丹尼尔·s·巴A1安德里亚;8:32 A1 Neda; 8:32年2019 UL //www.ez-admanager.com/content/92/19/e2209.abstract AB客观评估是否海马硬化(HS)严重程度是反映的大规模网络。首页方法我们研究术前高分辨率的解剖和diffusion-weighted MRI 44颞叶癫痫患者(框架)病理诊断HS (n = 25;TLE-HS)和孤立的神经胶质过多症(n = 19;TLE-G)和25名健康对照组。海马测量包括基于分区映射的萎缩和T2 hyperintensity索引细胞损失和神经胶质过多症,分别。整个大脑连接体通过扩散tractography生成和检查使用图论以及一种新的网络控制理论范式,模拟功能的动力学结构网络数据。我们观察到的结果与控制相比,显著增加了路径长度和降低集群TLE-HS控制相比,表明降低全球和本地网络的效率,而TLE-G显示只有细微的变化。同样,网络可控性低TLE-HS,表明有限范围的功能动态。海马成像标记是积极与大规模网络的改变,尤其是在侧CA1-3。系统评估跨多个网络显示最大海马迂曲的变化。 Findings were consistent when correcting for cortical thickness, suggesting independence from gray matter atrophy.Conclusions Severe HS is associated with marked remodeling of connectome topology and structurally governed functional dynamics in TLE, as opposed to isolated gliosis, which has negligible effects. Cell loss, particularly in CA1-3, may exert a cascading effect on brain-wide connectomes, underlining coupled disease processes across multiple scales.AAL=automated anatomical labeling; FA=fractional anisotropy; FDR=false discovery rate; FOV=field of view; HS=hippocampal sclerosis; MPRAGE=magnetization-prepared rapid gradient echo; ROI=region of interest; TE=echo time; TI=inversion time; TLE=temporal lobe epilepsy; TLE-G=temporal lobe epilepsy with gliosis; TLE-HS=temporal lobe epilepsy with hippocampal sclerosis; TR=repetition time

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