TY -的T1 -等离子体的早期海拔Lipocalin-2 / NGAL与贫穷有关Neurofunctional蛛网膜下腔出血患者的结果(p5.3 - 027) JF -神经学乔-神经学六世- 92 - 15补充SP -方p5.3 - 027 AU - Yu盟艾莎Saand AU - Jong李盟Liangge H首页su盟明明宁非盟- Eng罗盟雪莉周Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_supplement/p5.3 - 027. -文摘N2 -目的:确定等离子Lipocalin-2 / NGAL之间的关系和功能结果在蛛网膜下腔出血(SAH)患者。背景:研究表明,神经炎症在SAH-associated脑损伤中起着至关重要的作用。在SAH Lipocalin-2 / NGAL介导神经炎症动物模型。在这里,我们假设Lipocalin-2 / NGAL SAH患者与功能相关的结果。设计/方法:我们从SAH包括67名被试群体倾斜连续血液样本和前瞻性评价改良Rankin规模(夫人)得分每隔3个月。可怜的功能性结果被定义为夫人比;2。血管造影血管痉挛被定义为在减少50%的口径船后脑血管痉挛。任何提出超出96小时的SAH患者发病,有二级SAH或其他颅内优秀条件(恶性肿瘤、脑膜炎等)和慢性肾脏或肝脏疾病被排除在外。Lipocalin-2 / NGAL测量使用人类磁Luminex化验(R& D系统)在第一天,3和5篇文章长官。 Patients with unruptured cerebral aneurysm were included as control group (N=19). Continuous variables were compared with Student’s t or Wilcoxon rank sum test depending on data distribution. One-way ANOVA was applied for comparison among more than 2 groups.Results: The overall cohort had mean age of 55.1 years and had 69% women. Majority of the cohort had Hunt and Hess grade 3 or above (67%) and modified Fisher grade 3–4 (89%). Overall, 48% and 36% patients developed poor outcome at 3- and 6-month post SAH, and 55% developed vasospasm. Within the SAH cohort, higher lipocalin-2/NGAL and Ln lipocalin-2/NGAL were associated with poor 3-month outcome (p=0.0044) and poor 6-month outcome (p=0.0417), respectively.Conclusions: Early elevation of plasma Lipocalin-2/NGAL is associated with poor neurofunctional recovery in SAH patients. Detailed mechanisms are needed to understand the role of Lipocalin-2/NGAL in SAH and develop potential Lipocalin-2/NGAL-based therapy.Disclosure: Dr. Yu has nothing to disclose. Dr. Saand has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Hsu has nothing to disclose. Dr. Ning has nothing to disclose. Dr. Lo has nothing to disclose. Dr. Chou has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Edge Therapeutics, and Merck & Co. Dr. Chou has received royalty, license fees, or contractual rights payments from VL39 9Flagship, and Venture/Massachusetts General Hospital. ER -