TY -的T1 Flotillin-1/2自身抗体在中枢神经系统炎症性疾病患者(p2.2 - 072) JF -神经学乔-神经学六世- 92 - 15补充SP - p2.2 - 072 AU -萨拉Mariotto AU 首页-阿尔贝托Gajofatto盟Daniela阿尔贝蒂AU - Sabine莱德尔盟萨尔瓦多摩纳哥AU -塞尔吉奥·法拉利非盟和平Hoeftberger Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_supplement/p2.2 - 072. -文摘N2 -目的:分析Flotillin-1/2复杂的自身抗体(Flot-Ab)否则血清反应阴性的患者炎性中枢神经系统(CNS)的条件;描述的特点Flot-Ab血清反应阳性的病例。背景:Flotillin 1和Flotillin 2最近确定为目标抗原在某些多发性硬化症患者。然而,只有14个病例报告到目前为止,在一个单一的报告。设计/方法:血清和可用时,脑脊液样本的特征明显特发性炎性中枢神经系统疾病患者神经单元,维罗纳大学医院,2014年3月至2018年5月被分析Flot-Ab利用细胞试验(Euroimmun,吕贝克)。首页免疫组织化学在老鼠大脑中执行Flot-Ab积极性。在第二部分的研究中,受试者被称为神经病理学实验室,维也纳大学,显示类似的特殊免疫组织化学模式综述了Flot-Ab分析和选择。结果:患者的分析研究多发性硬化(N = 43),临床孤立综合征(N = 15),特发性视神经炎(N = 84)、急性脊髓炎(N = 42),视neuromyelitis (N = 4),视神经炎和脊髓炎(N = 8)。其中,一个进步的多发性硬化症患者阳性血清和CSF Flot-Ab。这个病人表现出特有的细粒度在免疫组织化学染色在老鼠大脑海马和小脑。 Two additional cases then selected based on the immunohistochemical pattern resulted also positive for Flot-Ab. One of these cases had a final diagnosis of multiple sclerosis (only serum available for Flot-Ab analysis), while in the other (positive in both serum and CSF) the differential diagnosis between a vascular and a demyelinating disorder is still debated.Conclusions: Flotillin 1/2 might be a target antigen in patients with inflammatory CNS disorders, introducing potential new insight into the differential diagnosis of these conditions.Disclosure: Dr. Mariotto has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Merck & Co., Inc. Dr. Gajofatto has received research support from Research support funding from Merck. Dr. Alberti has nothing to disclose. Dr. Lederer has nothing to disclose. Dr. Monaco has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen. Dr. Ferrari has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Shire for attending a neurological meeting in Italy. Dr. Hoeftberger has nothing to disclose. ER -