PT -期刊文章又是AU -科尔刺伤盟Turcano盟——亚历山德拉Wennberg AU -基思·约瑟夫盟-詹姆斯·鲍尔AU - j . Ahlskog AU -布拉德利Boeve盟David Knopman盟Rodolfo Savica TI -进行性核上的麻痹和Corticobasal综合症的发病率和趋势在奥姆斯特德县:基于人口的研究(1995 - 2005)。(p3.8 - 003) DP - 2019年4月09年TA -神首页经病学第六PG - p3.8 - 003 - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_supplement/p3.8 003. - 003.短4100 - //www.ez-admanager.com/content/92/15_supplement/p3.8 - -全所以Neurology2019 4月09年;92 AB -目的:探讨进行性核上的脑瘫的发病率和趋势(PSP)和Corticobasal综合症(CBS)在奥姆斯特德县事件以人群为基础的队列研究中,锰。背景:很少有研究调查了PSP的发病率和哥伦比亚广播公司(CBS)的人口由于其罕见。设计/方法:我们使用了1991 - 2005年的事件以人群为基础的队列研究帕金森症在奥姆斯特德县,通过定义MN罗彻斯特流行病学项目。运动障碍专家审查所有的医疗记录确认诊断。结果:我们发现21例在我们群;18/21(85.7%)的被诊断为PSP,而3/21(14.3%)哥伦比亚广播公司(CBS)的临床诊断。诊断时的平均年龄是78岁(范围:66 - 88)。13/21(62.0%)是男性。进行MRI在诊断前10位病人(7 PSP和3 CBD),只有一个显示皮质萎缩的临床诊断。两个PSP的病人进行了解剖和临床和病理诊断之间的一致性。 The combined incidence for PSP and CBS in Olmsted County, MN was 3.1/100,000 (95% CI 1.7, 4.4, P< 0.001); the incidence was higher in men (4.5, 95% CI, 2.0–7.0, P< 0.001) than women (1.8, 95% CI, 0.5–2.9, P< 0.001). CBS incidence was 0.4/100,000 (95% CI 0.0, 0.9, P<0.001); PSP incidence was 2.6/100,000 (95% CI 1.4, 3.8, P<0.001). When combined a significant trend of increasing incidence was observed between 1991–2005 (B=0.69, 95% CI 0.42, 0.96, p<0.001).Conclusions: The combined incidence for PSP and CBS was 3.1/100,000 in our cohort and was higher in men than women. We observed a relevant increase in the trend of the incidence of both PSP and CBS, which is likely due to advancing imaging technology and improved diagnostic ability among physicians.Disclosure: Dr. Stang has nothing to disclose. Dr. Turcano has nothing to disclose. Dr. Wennberg has nothing to disclose. Dr. Josephs has nothing to disclose. Dr. Bower has nothing to disclose. Dr. Ahlskog has nothing to disclose. Dr. Boeve has received research support from Biogen. Dr. Knopman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Washington University for the DIAN study. Dr. Knopman has received research support from Biogen Pharmaceuticals and Lilly Pharmaceuticals. Dr. Savica has nothing to disclose.