RT期刊文章SR电子T1白质Hyperintensities和海马萎缩与认知:90 +研究(S34.005)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP S34.005 VO 92 15补充A1 Nienke Legdeur A1 Dana G首页reenia A1戴维斯Woodworth A1埃文·弗莱彻A1 Charles DeCarli A1克劳迪娅川A1玛丽亚Corrada年2019 UL //www.ez-admanager.com/content/92/15_Supplement/S34.005.abstract AB目的:学习的互动影响白质Hyperintensities(负责人)和海马萎缩在长寿老人的认知。背景:认知功能在年龄在90岁及以上(长寿老人)是由多种因素决定的。认知障碍之间的关系和个人疾病似乎随着年龄的增长变得较弱。然而它仍然是未知的长寿老人的这些不同的病态是如何交互的。设计/方法:受试者141人(94年认知正常和47认知障碍)。每个参与者的大脑核磁共振扫描完成。认知测试每六个月进行平均2.0年的随访中,包括以下测试:细微精神状态检查(MMSE)、修改MMSE(3)女士,加州言语学习测试(CVLT)立即召回超过四个试验和延迟回忆,数字广度落后,动物流利,跟踪测试(TMT), B和c的一个线性混合模型是用于每个认知测试基线和纵向研究协会负责人和海马体积与认知。模型调整年龄、性别和教育。结果:研究样本的平均年龄是94.3 (SD = 3.2)年。在基线,更高的负责人卷与糟糕的分数3毫秒,CVLT直接和延迟回忆和TMT b降低海马体积与糟糕的基线认知测试成绩,除了数字广度落后。纵向,更高的负责人和更低的海马体积与速度下降3女士和MMSE和降低海马体积也更快下降CVLT立即召回。 There was no association between WMH and hippocampal volume and no interaction between WMH and hippocampal volume in their association with baseline cognition or cognitive decline.Conclusions: The research shows that WMH and hippocampal atrophy have an independent, and not synergistic, negative effect on cognition in the oldest-old.Disclosure: Dr. Legdeur has nothing to disclose. Dr. Greenia has nothing to disclose. Dr. Woodworth has nothing to disclose. Dr. Fletcher has nothing to disclose. Dr. DeCarli has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Novartis Pharmaceuticals. Dr. Kawas has nothing to disclose. Dr. Corrada has nothing to disclose.