TY -的T1 Levodopa-induced典型震颤麻痹运动障碍:以人群为基础的队列研究(p3.8 - 011) JF -神经学乔-神经学六世- 92 - 15补充SP - p3.8 - 011 AU -又是Turcano AU 首页-科尔刺伤AU -詹姆斯·鲍尔AU -亚历山德拉Wennberg AU - j . Ahlskog AU -米歇尔Mielke盟Rodolfo Savica Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_supplement/p3.8 - 011. -文摘N2 -目的:调查Levodopa-induced运动障碍的人口基数的非典型震颤麻痹。背景:很少有研究调查levodopa-induced典型帕金森症的运动障碍。设计/方法:我们在1991 - 2010年以人群为基础的parkinsonism-incident群奥姆斯特德县,MN,我们确定了所有的非典型帕金森症患者和抽象信息levodopa-induced运动障碍。我们随后相比典型帕金森症患者的帕金森病(PD)患者相同的人口基数。结果:左旋多巴的数据使用和运动障碍可用于337/344典型帕金森症患者(98.0%)。其中,150例(44.5%)与左旋多巴治疗;11.3%的levodopa-treated患者运动障碍。运动障碍的患者,平均诊断年龄为73.5岁(范围:54 - 80),58.8%是男性,平均随访时间从左旋多巴启蒙运动障碍发病是3年(范围:2 - 5),和左旋多巴的剂量中值为600毫克(范围:300 - 900)。运动障碍严重程度导致了左旋多巴的调整或金刚烷胺引发八个病人,改善7。运动障碍患者被诊断出患有帕金森症明显在年轻患者相比无运动障碍(p = 0.03),没有其他组之间的差异。在模型中调整年龄、性别、和左旋多巴剂量,典型的帕金森症患者PD患者相比发展运动障碍的几率也低(或= 0.31,95% CI 0.17, 0.57;术中,0.001)。 However, in analysis combing atypical parkinsonism and PD patients, higher dose of levodopa was associated with higher odds of dyskinesia, independent of age, sex, and diagnosis (OR=3.39, 95% CI 1.82, 6.32, p<0.001). Five dyskinetic patients underwent autopsy and the pathological diagnosis was consistent with the clinical diagnosis.Conclusions: Levodopa-induced dyskinesia affected only 11.3% of patients with atypical parkinsonism. Atypical parkinsonisms are associated with lower odds of developing levodopa-induced dyskinesia compared to PD, independent of levodopa dose.Disclosure: Dr. Turcano has nothing to disclose. Dr. Stang has nothing to disclose. Dr. Bower has nothing to disclose. Dr. Wennberg has nothing to disclose. Dr. Ahlskog has nothing to disclose. Dr. Mielke has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Lysosomal Therapeutics, Inc. Dr. Mielke has received research support from Biogen, Roche, and Lundbeck. Dr. Savica has nothing to disclose. ER -