TY - T1的额颞叶大叶性变性的鉴别诊断长寿老人(p3.1 - 009) JF -神经学乔-神经学六世- 92 - 15补充SP - p3.1 - 009 AU -林赛Embree盟约书亚Sonnen AU -约翰·霍夫曼盟首页主管Yoshimi Anzai盟达斯汀锤子AU -阿曼达·库希拉AU -诺曼·福斯特Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_supplement/p3.1 009. -抽象N2 -目的:目前的临床特征、脑成像和尸检结果在一个90岁的女人TDP-43积极行为变异额颞叶退化(BvFTD)。背景:额颞叶退化报道很少,没有尸检确认长寿老人和通常不被认为是在这个年龄段的鉴别诊断。此外,先进的大脑成像识别的可靠性FTD在这个年龄段的问题。设计/方法:一个90岁的女人首先寻求医疗建议当她失语症和记忆缺失。最初的临床印象广告与远程脑梗塞;然而,缄默症,症状发展迅速超过6个月ADL障碍、震颤麻痹。进一步审问,人格改变的家庭支持隐性发病,妄想在几年和抑制行为。评估包括核磁共振、脑电图和脊髓液检查。正进行区分FTD的广告。结果:脑MRI表示深刻的双时态和额叶萎缩。同样,正/ CT发现双边中度/重度前颞前扣带和额叶代谢减退与BvFTD一致。 In addition, there was mild/moderate hypometabolism in the parietal, posterior cingulate and precuneus cortex bilaterally making it impossible to unequivocally exclude AD. The patient died 4 months later and brain autopsy was performed. There were low/intermediate pathologic changes of AD with neuritic plaques but a low Braak stage (A1, B1, C3 by NIA-AA criteria). This level of AD pathology is insufficient to account for dementia. Immunohistochemistry demonstrated numerous ubiquitin neuronal and glial inclusions that did not co-localize with tau pathology. Immunohistochemistry for TDP-43 was subsequently performed revealing intraneuronal cytoplasmic inclusions. Genetic testing found a tau variant associated with both AD and FTD.Conclusions: Advanced age does not exclude FTD and should be considered in the differential diagnosis, even in the oldest-old. Further, multiple pathologies are common in the oldest old. Advanced brain imaging including MRI, FDG-PET can help identify non-AD dementias in elderly.Disclosure: Dr. Embree has nothing to disclose. Dr. Sonnen has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities. Dr. Hoffman has nothing to disclose. Dr. Anzai has nothing to disclose. Dr. Hammers has nothing to disclose. Dr. Kucera has nothing to disclose. Dr. Foster has nothing to disclose. ER -