PT -期刊文章盟Shemonti哈桑盟-米歇尔Mielke AU - j . Ahlskog AU -詹姆斯·鲍尔盟又是Turcano AU - Rodolfo Savica TI -前感染导致住院或脓毒症临床诊断α-synucleinopathies:一项病例对照研究在奥姆斯特德县,MN (1991 - 2010)。(p3.8 - 049) DP - 2019年4月09年TA -神首页经病学第六PG - p3.8 - 049 - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_supplement/p3.8 049. - 049.短4100 - //www.ez-admanager.com/content/92/15_supplement/p3.8 - -全所以Neurology2019 4月09年;92 AB -目的:我们研究了感染之间的关系复杂化住院或败血症和任何类型的α-synucleinopathies的发展。背景:很少有研究评估α-synucleinopathies内人口和研究了曝光,如感染,与每个类型相关联。设计/方法:我们使用的医疗records-linkage系统罗彻斯特流行病学项目识别所有病例α-synucleinopathies奥姆斯特德县从1991年到2010年。每种情况下被年龄匹配(+ /−1年)症状出现和性的一般人群控制。我们回顾了完整的医疗记录的病例和控制检测感染需要住院治疗运动症状出现之前α-synucleinopathies任何类型的。对于每一个感染,败血症发展我们也回顾了。我们使用条件逻辑回归计算所有α-synucleinopathies的优势比,以及类型。结果:至少一个感染导致住院的历史与0.76折的可能性下降α-synucleinopathy诊断任何类型的单变量分析(95%置信区间:0.58 - -0.99,p = 0.04)。在分析按类型时,没有具体的α-synucleinopathies明显与感染导致住院治疗。 Although sepsis was less frequent among the cases compared to the matched controls (12 cases (2.6%) vs. 16 cases (3.4%)), sepsis was not significantly associated with α-synucleinopathies of any type (OR: 0.75, 95% CI 0.35–1.59, p=0.50).Conclusions: Infections leading to hospitalization was associated with decreased risk of developing any α-synucleinopathy. Future analysis will determine if certain types of infections, antibiotics, or even length of hospital stay contribute to and further explain these findings.Disclosure: Dr. Hasan has nothing to disclose. Dr. Mielke has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Lysosomal Therapeutics, Inc. Dr. Mielke has received research support from Biogen, Roche, and Lundbeck. Dr. Ahlskog has nothing to disclose. Dr. Bower has nothing to disclose. Dr. Turcano has nothing to disclose. Dr. Savica has nothing to disclose.