PT -期刊文章盟莫莉Ungrady AU -卡洛琳王盟- Katheryn A.Q.兄弟盟穆雷格罗斯曼TI -分离对象和知识在颞叶和顶叶疾病:分区语义记忆及其功能后果(S13.005) DP - 2019年4月09年TA -神经病学PG - S13.005 VI - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_Supplement/S13.005.short 4100 - //www.ez-admanager.com/content/92/15_Supplement/S13.005.f首页ull所以Neurology2019 4月09年;92 AB -目标:我们的目标是确定一个双赤字的离解对象和知识在语义记忆和数量证明不爱交际的实际功能的后果有选择地语义记忆受损。背景:数量和规模,与顶叶,和对象的知识,与颞叶,是语义记忆的两个领域。我们推测,这些解剖不同领域的知识会有选择地顶叶和颞疾病,患者受损,这将有选择性地影响日常生活功能。设计/方法:我们评估患者颞(语义变体原发性进行性失语,n = 6)和顶叶疾病(corticobasal综合症,后皮质萎缩,n = 15)。组匹配的教育、疾病持续时间和年龄。我们派生对象语义知识得分平均对象的z分数知识的措施(金字塔和棕榈树测试,叉子和筷子测试)和numerosity知识平均得分的z分数的措施评估数字意识和大小(简单的精神之外,dot-array-Arabic-numeral匹配)。功能评估包括日常生活活动量表(ADL)和感知对话Index-Dementia阿尔茨海默氏症的类型(PCI-DAT)。结果:t表示对象知识得分明显比numerosity得分(术中;0.01)时间组,但明显比numerosity壁组的得分(术中,0.05)。颞组表现出更大对象知识得分(术中,0.05)和更好numerosity得分比壁组织(术中,0.05)。PCI-DAT分数明显恶化的时间组比壁组(术中,0.001)和与对象相关知识得分(术中,0.01)。无论是对象还是numerosity ADL相关知识。Conclusions: Results suggest a double dissociation within semantic memory of object and numerosity knowledge. Impaired object knowledge entails a functional deficit in communication, but neither semantic impairment impacts activities of daily living.Disclosure: Dr. Ungrady has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Cousins has nothing to disclose. Dr. Grossman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with GE Whitney. Dr. Grossman has received personal compensation in an editorial capacity for Neurology. Dr. Grossman has received research support from Biogen.