TY - T1的皮层和皮层下协会Aβ沉积与抑郁和焦虑症状:以人群为基础的横断面研究(p5.1 - 028) JF -神经学乔-神经学六世- 92 - 15补充SP - p5.1 - 028 AU -怪不得我Krell-Roesch AU -玛丽亚Vassilaki盟杰里米Syrjanen AU -妮可Curnutt AU -大首页卫Gritsch盟Prashanthi Vemuri AU -米歇尔Mielke AU - Val劳盟-克利福德杰克AU -沃尔特·克雷默盟David Knopman盟Gorazd Stokin AU -罗纳德·彼得森AU - Y1 Yonas Geda 2019/04/09 UR - //www.ez-admanager.com/content/92/15_supplement/p5.1 028. -抽象N2 -目的:探讨皮层与皮层下β-amyloid之间的联系(Aβ)沉积与抑郁和焦虑症状在老年人认知能力受损(铜)。背景:神经精神症状与神经影像学相关生物标志物的上下文中异常大脑衰老。小被称为是否有大脑皮层和皮层下Aβ沉积的区别及其与抑郁和焦虑症状。设计/方法:我们进行了一项横断面研究来源于衰老的梅奥诊所以人群为基础的研究,包括铜≥70岁的人。参与者接受PiB-PET评估Aβ沉积在大脑皮层和皮层下(即纹状体、丘脑、杏仁核)地区,并完成了贝克抑郁量表(BDI-II)和贝克焦虑量表(BAI)。我们跑了线性回归分析研究大脑皮层和皮层下PiB-PET协会(如连续措施)与抑郁和焦虑症状(BDI /白得分)。模型调整年龄、性别、教育、和APOEɛ4载体状态。结果:样本由842立方的人(平均78.3(5.4)岁(SD);平均(SD)教育14.6(2.8)年;54%的男性,26%的APOEɛ4运营商)。皮层下PiB-PET与BDI(估计0.0748;p = . 05)和白分数(est。0.0734; p = .05). Cortical PiB-PET was associated with BDI scores (est. 0.0963; p <.05) only. When we stratified by APOE ɛ4 carrier status, we observed that subcortical PiB-PET was associated with BDI scores (est. 0.1135; p <.05) only in APOE ɛ4 non-carriers. Similarly, cortical PiB-PET was associated with BDI (est. 0.1102; p <.05) and BAI scores (est. 0.0988; p <.05) in APOE ɛ4 non-carriers.Conclusions: Elevated subcortical Aβ deposition might be associated with greater depressive and anxiety symptoms in community-dwelling CU older adults, especially in APOE ɛ4 non-carriers. This cross-sectional observation merits further investigation and needs to be confirmed by a prospective cohort study.Disclosure: Dr. Krell-Roesch has nothing to disclose. Dr. Vassilaki has received research support from Roche, Biogen. Dr. Syrjanen has nothing to disclose. Dr. Curnutt has nothing to disclose. Dr. Gritsch has nothing to disclose. Dr. Vemuri has nothing to disclose. Dr. Mielke has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lilly and Lysosomal Therapeutics, Inc. Dr. Mielke has received research support from Biogen, Roche, and Lundbeck. Dr. Lowe has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Bayer Schering Pharma, Piramal Life Sciences. Dr. Lowe has received research support from GE Healthcare, Siemens Molecular Imaging, AVID Radiopharmaceuticals. Dr. Jack has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eli Lily. Dr. Kremers has received research support from Astra Zeneca, Biogen and Roche. Dr. Knopman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Washington University for the DIAN study. Dr. Knopman has received research support from Biogen Pharmaceuticals and Lilly Pharmaceuticals. Dr. Stokin has nothing to disclose. Dr. Petersen has nothing to disclose. Dr. Geda has received research support from Roche Diagnostics Corporation. ER -