PT -期刊文章盟布莱恩史密斯盟Ulisses Santamaria AU -伊丽莎白·霍恩盟Ankit Saxena AU -菲利普本人非盟-约瑟夫·雪盟Avindra Nath TI -不同的神经退行性和神经炎症亚型艾滋病神经认知障碍(手)(S29.007) DP - 2019年4月09年TA -神经病学PG - S29.007 VI - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_Supplement/S29.007.short 4100 - //www.ez-admanager.com/content/92/15_S首页upplement/S29.007.full所以Neurology2019 4月09年;92 AB -目的:识别不同的HIV(+)组定义为脑脊液异常和比较这些组织与正常脑脊液概要文件来确定对临床结果。背景:手被定义为可怜的神经心理学(NP)测试性能,然而标准特异性的和有较高的假阳性率。这使得标志物困难,因为手的原因不能反映一个单一的疾病实体。设计/方法:参与者完成一个全面的NP电池和一个研究腰椎穿刺。HIV (+) (n = 67)和艾滋病(−)控制(n = 21)组没有年龄差异,性别或种族。所有HIV(+)参与者有血浆HIV病毒载量& lt; 40 c /毫升在抗逆转录病毒治疗(平均时间12.7年)。神经退行性和神经炎症组被定义为那些HIV(+)患者CSF水平的神经丝轻链(NFL)或tnf,分别测量了Quanterix SIMOA免疫测定,超过三个标准差以上对照组的意思。细胞因子测定,tnf是用来定义神经炎症组,因为它有最大的区别HIV(+)和对照组(术中,0.01)。结果:与正常脑脊液剖面相比,神经退行性组(n = 9)更有可能满足手标准(75%比18%,术中;0.01)和有一个异常GDS(83%比21%,术中;0.01)。没有不同的比例与CSF逃脱(13%比12%)。神经炎症组(n = 15)没有不同比例与正常脑脊液手相比,有一个轻微的趋势有更多CSF逃脱(20%比8%,p = 0.2)。Conclusions: By defining subsets within the HIV (+) group using CSF abnormalities, we have demonstrated that different pathogenic mechanisms exist within this population, with different clinical outcomes for each group. Essentially, what has been defined traditionally as HAND represents distinct diseases that require unique interventions for future research.Disclosure: Dr. Smith has nothing to disclose. Dr. Santamaria has nothing to disclose. Dr. Horne has nothing to disclose. Dr. Saxena has nothing to disclose. Dr. McCoy has nothing to disclose. Dr. Snow has nothing to disclose. Dr. Nath has received personal compensation in an editorial capacity for Practice Update Neurology.

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