TY - T1的组织病理学扩散成像异常脑淀粉样血管病JF -神经学乔-神经病学SP - e933 LP - e943做- 10.1212 / WNL。首页0000000000007005六世- 92 - 9 AU - Susanne j . van据称盟雅艾尔·d·Reijmer AU -安德烈·j·范德韦盟Andreas Charidimou盟恩典a Riley盟-亚历山大Leemans盟布莱恩j . Bacskai AU -马修·p·就诊盟Anand Viswanathan AU -史蒂文·m·格林伯格Y1 - 2019/02/26 UR - //www.ez-admanager.com/content/92/9/e933.abstract N2 -目标我们试图确定底层机制改变白质弥散张量成像(DTI)措施在病理级别患者脑淀粉样血管病首页(CAA)。方法Formalin-fixed完整半球从9 CAA例和2老年人控制在3-tesla MRI扫描,包括diffusion-weighted序列。DTI措施(即。,分数各向异性(FA)和平均扩散系数(MD))和组织病理学措施获得2大片:前丘脑辐射伪劣纵向纤维束。结果FA减少大片和MD在例CAA相比,增加了控制。区域FA明显与组织稀疏,白质髓鞘密度、轴突密度,和微型心肌梗塞的可能性。MD显著相关,组织稀疏,髓鞘密度,和白质微型心肌梗塞的可能性,但不是轴突密度。FA和MD没有与胶质细胞星形胶质细胞、神经胶质过多症。多变量分析显示,组织稀疏(β=−0.32±0.12,p = 0.009)和轴突密度(β= 0.25±0.12,p = 0.04)都是独立与FA相关,而髓密度是独立与MD(β=−0.32±0.12,p = 0.013)。最后,我们发现一个协会之间更多的医学博士在额叶白质和CAA严重性额叶皮质(p = 0.035)。结论这些结果表明,整体组织损失,特别是轴突和髓鞘脱落,是主要的组件基础CAA-related DTI属性改变生活的观察病人。 The findings allow for a more mechanistic interpretation of DTI parameters in small vessel disease and for mechanism-based selection of candidate treatments to prevent vascular cognitive impairment.AD=axial diffusivity; ATR=anterior thalamic radiation; CAA=cerebral amyloid angiopathy; DTI=diffusion tensor imaging; FA=fractional anisotropy; GFAP=glial fibrillary acidic protein; H&E=hematoxylin & eosin; ILF=inferior longitudinal fasciculus; LFB&H=Luxol fast blue & hematoxylin; MBP=myelin basic protein; MD=mean diffusivity; MGH=Massachusetts General Hospital; NF200=neurofilament 200; RD=radial diffusivity; ROI=region of interest; SVD=small vessel disease; TBS=tris-buffered saline; TE=echo time; TR=repetition time; True FISP=true fast imaging with steady-state free precession ER -

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