PT -期刊文章盟吉纳维芙雷纳AU -克里斯Tailby盟格雷姆杰克逊AU -莎拉·威尔逊TI -病变以外寻找导致癫痫的神经心理障碍- 10.1212 / WNL援助。0000000000006905 DP - 2019年2月12日TA -神经病首页学PG - e680 e689 VI - 92 IP - 7 4099 - //www.ez-admanager.com/content/92/7/e680.short 4100 - //www.ez-admanager.com/content/92/7/e680.full所以Neurology2019 2月12;92 AB -目标患者颞叶癫痫(框架)是相似的癫痫学无论他们对MRI病灶明显;本研究旨在前瞻性说明是否也类似的神经心理档案。框架方法参与者由152名成人:79患者和73名健康对照组。病人和对照组没有不同年龄、性别、或教育(p比;0.05)。百分之六十二的患者有一个MRI-resolvable病变(39%认为海马硬化[HS-TLE], 61%的病变除了HS[框架MRI-positive]);剩下的38%的患者lesion-negative。心理措施建立在癫痫。结果相对于控制,所有3患者亚组显示明显受损的自传,口头和视觉记忆(p & lt; 0.05–0.001) and significantly more depression and anxiety (p < 0.05–0.01). Yet, contrary to expectations, the 3 TLE subgroups did not differ in their severity of memory or mood impairment (p > 0.05). Lower Full-Scale IQ predicted memory impairments across all TLE subtypes, with early age at seizure onset a predictor unique to MRI-negative TLE.Conclusions MRI-negative TLE is associated with memory and mood dysfunction equivalent to that seen in patients with hippocampal sclerosis and other MRI-resolvable pathologies. As such, neuropsychological impairments in TLE are not contingent on a macroscopic lesion and might be an intrinsic property of the underlying network disease.AMI=Autobiographical Memory Interview; ANCOVA=analysis of covariance; CI=confidence interval; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); ES=effect size; FSIQ=Full-Scale IQ; HS=hippocampal sclerosis; HS-TLE=temporal lobe epilepsy with hippocampal sclerosis; MRI-neg TLE=MRI-negative temporal lobe epilepsy; MRI-pos TLE=MRI-positive temporal lobe epilepsy; NDDI-E=Neurological Disorders Depression Inventory for Epilepsy; PHQ-GAD-7=Patient Health Questionnaire–Generalized Anxiety Disorder 7-item; ROCF=Rey-Osterrieth Complex Figure; SCID=Structured Clinical Interview for DSM-IV Axis I Disorders; TLE=temporal lobe epilepsy; VPA=Verbal Paired Associates