@article {Raynere680作者={吉纳维芙雷纳和克里斯Tailby格雷姆·杰克逊和莎拉·威尔逊},title ={病变以外寻找导致癫痫的神经心理障碍},体积={92}={7},页面= {e680——e689} = {2019}, doi = {10.1212 / WNL。出版商0000000000006905}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目标患者颞叶癫痫(框架)是相似的癫痫学无论他们对MRI病灶明显;首页本研究旨在前瞻性说明是否也类似的神经心理档案。框架方法参与者由152名成人:79患者和73名健康对照组。病人和对照组没有不同年龄、性别、或教育(p \ > 0.05)。百分之六十二的患者有一个MRI-resolvable病变(39 \ %与假定海马硬化[HS-TLE], 61 \ %病变除了HS[框架MRI-positive]);其余的38 lesion-negative \ %的患者。心理措施建立在癫痫。结果相对于控制,所有3患者亚组显示明显受损的自传,口头和视觉记忆(p \ < 0.05 {\ textendash} 0.001)和更多的抑郁和焦虑(p \ {\ textendash} 0.01 p < 0.05)。然而,框架与预期相反,3组没有内存或情绪障碍的严重程度不同(p \ > 0.05)。智商低的全面预测所有框架的记忆障碍亚型,与早期癫痫发作预测框架MRI-negative独有。结论MRI-negative框架与记忆和情绪障碍与海马硬化患者和其他MRI-resolvable病态。 As such, neuropsychological impairments in TLE are not contingent on a macroscopic lesion and might be an intrinsic property of the underlying network disease.AMI=Autobiographical Memory Interview; ANCOVA=analysis of covariance; CI=confidence interval; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); ES=effect size; FSIQ=Full-Scale IQ; HS=hippocampal sclerosis; HS-TLE=temporal lobe epilepsy with hippocampal sclerosis; MRI-neg TLE=MRI-negative temporal lobe epilepsy; MRI-pos TLE=MRI-positive temporal lobe epilepsy; NDDI-E=Neurological Disorders Depression Inventory for Epilepsy; PHQ-GAD-7=Patient Health Questionnaire{\textendash}Generalized Anxiety Disorder 7-item; ROCF=Rey-Osterrieth Complex Figure; SCID=Structured Clinical Interview for DSM-IV Axis I Disorders; TLE=temporal lobe epilepsy; VPA=Verbal Paired Associates}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/92/7/e680}, eprint = {//www.ez-admanager.com/content/92/7/e680.full.pdf}, journal = {Neurology} }