TY -的T1 -τ之间的关联,Aβ,皮质厚度与认知神经学在阿尔茨海默病JF -神经学乔- SP - e601 LP - e612做- 10.1212 / WNL。首页0000000000006875六世- 92 - 6非盟-里克Ossenkoppele AU -鲁本史密斯AU -托马斯欧胜盟Olof Strandberg AU - Niklas马特盟Philip s . Insel AU -塞巴斯蒂安Palmqvist盟奥斯卡·汉森Y1 - 2019/02/05 UR - //www.ez-admanager.com/content/92/6/e601.abstract N2 -客观检查区域之间的横向联系τ,β-首页amyloid (Aβ)和皮质厚度和神经心理功能的临床前和临床阿尔茨海默病(AD)。瑞典生物标志物的方法包括106名参与者识别早期神经退行性疾病和可靠(BioFINDER)研究中,其中33个临床前广告(Aβ-positive认知正常的个人),25了前驱的广告(Aβ-positive轻度认知障碍)和48可能AD痴呆。所有接受[18 f] flortaucipir(τ)和结构磁共振成像(皮质厚度),106年和88年经历了[18 f] flutemetamol (Aβ)宠物。线性回归模型调整年龄、性别、和教育进行检查7地区利益和7之间的关联神经心理学测试3成像模式。结果在临床前的广告,[18 f] flortaucipir,但不是[18 f] flutemetamol或皮质厚度与减少全球认知、记忆和处理速度(射程标准化β= 0.35 - -0.52,p & lt;0.05未修正的多个比较)。在合并后的前驱的广告和广告痴呆组,既增加[18 f] flortaucipir吸收和减少皮质厚度与更差的性能在各种有关神经心理测试(大部分地区感兴趣的幸存校正为多个比较p & lt;0.05),同时增加[18 f] flutemetamol吸收是专门降低分数延迟回忆记忆任务(p & lt;0.05未修正的多个比较)。最强的影响[18 f] flortaucipir和皮质厚度在外侧和内侧认知发现顶叶皮层和颞皮层外侧。 The effect of [18F]flutemetamol on cognition was generally weaker and less region specific.Conclusion Our findings suggest that tau PET is more sensitive than Aβ PET and measures of cortical thickness for detecting early cognitive changes in preclinical AD. Furthermore, both [18F]flortaucipir PET and cortical thickness show strong cognitive correlates at the clinical stages of AD.Aβ=β-amyloid; AD=Alzheimer disease; ADAS=Alzheimer's Disease Assessment Scale; AQT=A Quick Test for Cognitive Speed; BioFINDER=Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably; FDR=false discovery rate; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; PVE=partial volume effects; ROI=region of interest; SUVR=standardized uptake value ratio; TMT-A=Trail Making Test A ER -