TY - T1的脑震荡基本III JF -神经学乔-神经病学SP - e2133 L首页P - - 10.1212 / WNL e2143做。0000000000006617六世- 91 - 23盟布列塔尼的m . Asken AU -拉塞尔·m·鲍尔盟史蒂文·t·DeKosky盟——Adrian m.f Svingos盟——加布里埃尔Hromas AU -乔纳森·k·布恩盟Dewayne n DuBose AU -罗纳德·l·海耶斯盟(James r . Clugston Y1 - 2018/12/04 UR - //www.ez-admanager.com/content/91/23/e2133.abstract N2 -目的探讨血清生物标志物浓度变化(β-首页amyloid肽42 (Aβ42),总τ,泛素carboxy-terminal水解酶L1, S100钙结合蛋白B (S100B),神经胶质原纤维酸性蛋白(GFAP),微管相关蛋白2 (MAP2),和2′,3′-cyclic-nucleotide 3′磷酸二酯酶[CNPase])体育运动相关的脑震荡后(SRC)大学生运动员的一个示例。对临床结果也被调查。参与者在这个病例对照研究方法包括36个运动员(50%为男性,61%是白人,19.7±1.0岁)和SRC。29还有基线血液,允许within-patient浓度变化的分析。群体间的分析结合86人口匹配控制(51%为男性,63%是白人,19.6±1.1岁)。生物标志物的敏感性和特异性SRC与控制和相对于标准化规范达标评估(接收机工作特性)。我们也分析了post-SRC临床结果之间的联系,从基线和post-SRC浓度生物标志物变化。结果大部分血液样本浓度GFAP、MAP2, CNPase低于量化的极限。SRC后Within-patient分析表明S100B升高(p = 0.003, 67%的患者升高),尤其是对血液样本收集& lt; 4小时post-SRC(88%的患者)。显著差异仅限于血液吸引& lt; 4小时post-SRC: Aβ42 (SRC祝辞的81%; control median, area under the curve [AUC] = 0.75 [95% confidence interval 0.59–0.91]), total tau (75% SRC > control, AUC = 0.74 [0.56–0.79]), and S100B (88% SRC > control; AUC [specific to white race] = 0.82 [0.72–0.93]). Using standardized normative cutoffs (z > 1.0), specificity ranged from 79.1% to 89.3% while sensitivity was <70%. Biomarkers were not associated with clinical outcomes.Conclusion For SRC, diagnostic accuracy of serum biomarkers appears best if blood is collected within a few hours. Accurate blood marker identification of SRC appears somewhat dependent on the “healthy” comparison. Additional research must evaluate whether physiologic changes in the absence of clinical changes, or vice versa, are relevant for concurrent or future neurologic health.Classification of evidence This study provides Class III evidence that certain serum biomarkers are elevated from baseline and higher than demographically matched controls after sport-related concussion.Aβ42=β-amyloid peptide 42; AUC=area under the curve; BASICS=Biomarkers Assessed in Collegiate Student-Athletes; CI=confidence interval; CNPase=2′,3′-cyclic-nucleotide 3′-phosphodiesterase; GFAP=glial fibrillary acidic protein; ImPACT=Immediate Postconcussion Assessment and Cognitive Testing; LLOQ=lower limit of quantification; MAP2=microtubule associated protein 2; SRC=sport-related concussion; UCH-L1=ubiquitin carboxy-terminal hydrolyzing enzyme L1 ER -