PT -期刊文章盟-热内罗Pagano盟与Polychronis AU -希瑟·威尔逊AU -贝尼亚米诺佐丹奴AU -尼古拉·费拉拉AU -弗Niccolini盟腻过politi TI -糖尿病和帕金森病- 10.1212 / WNL援助。0000000000005475 DP - 2018可能08年TA -神经病学首页PG - e1654 e1662 VI - 90 IP - 19 4099 - //www.ez-admanager.com/content/90/19/e1654.short 4100 - //www.ez-admanager.com/content/90/19/e1654.full所以Neurology2018可能08年;90 AB -目的探讨糖尿病是否与Parkinson-like病理学在人们没有帕金森病和评价糖尿病的影响帕金森病理学和临床进展的标记drug-naive患者早期帕金森病。方法我们比较25例帕金森病和糖尿病25没有糖尿病,糖尿病患者和14和帕金森病14健康对照组(没有糖尿病和帕金森病的人)。糖尿病的临床诊断证实了2连续空腹血清葡萄糖水平的测量在126 mL / dL。在提供3年的随访期间,然后调查人口与帕金森病的存在糖尿病是否与更快的汽车发展或认知能力下降有关。结果糖尿病的存在与运动成绩更高(p & lt;0.01),低纹状体多巴胺转运体绑定(p & lt;0.05)和τCSF水平较高(p & lt;0.05)在帕金森病的患者。糖尿病患者但没有帕金森病,糖尿病的存在是降低纹状体多巴胺转运体绑定(p & lt;0.05)和更高的τ(p & lt;0.05)和α-synuclein (p & lt; 0.05) CSF levels compared to healthy controls. At the Cox survival analysis in the population of patients with Parkinson disease, the presence of diabetes mellitus was associated with faster motor progression (hazard ratio = 4.521, 95% confidence interval = 1.468–13.926; p < 0.01) and cognitive decline (hazard ratio = 9.314, 95% confidence interval = 1.164–74.519; p < 0.05).Conclusions Diabetes mellitus may predispose toward a Parkinson-like pathology, and when present in patients with Parkinson disease, can induce a more aggressive phenotype.C-DM=controls with diabetes mellitus; CI=confidence interval; DM=diabetes mellitus; DMT=disease-modifying therapy; DPP-4=dipeptidyl peptidase-4; [123I]FP-CIT=[123I]-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane; GIP=glucose-dependent insulinotropic peptide; GLP-1=glucagon-like peptide 1; H&Y=Hoehn and Yahr; HC=controls without diabetes mellitus; HR=hazard ratio; MDS-UPDRS=Movement Disorder Society–Unified Parkinson’s Disease Rating Scale; MoCA=Montreal Cognitive Assessment; PD=Parkinson disease; PPMI=Parkinson's Progression Markers Initiative; ROI=region of interest; SBR=specific binding ratio