TY -的T1 Pre-diagnostic等离子体多不饱和脂肪酸和肌萎缩性脊髓侧索硬化症的风险(S4.003) JF -神经学乔-神经学六世- 90 - 15补充SP - S4.003盟Eilis O ' reilly盟Kjetil Bjornev首页ik AU -麦卡洛马约莉盟劳伦斯Kolonel AU - Loic Le玛珊德盟乔安曼森盟Alberto Ascherio博士Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/S4.003.abstract N2 -目的:检查Pre-diagnostic等离子体之间的联系多不饱和脂肪酸含量和肌萎缩性脊髓侧索硬化症(ALS)的风险。背景:潜在的病因机制ALS如氧化应激、炎症会引起,调制的多不饱和脂肪酸在大脑神经等离子体膜。个人饮食摄入量较高的n−3多不饱和脂肪酸ALS的风险较低。另一方面,高剂量摄入n−3 ALS的动物模型似乎加速发展。设计/方法:我们与275人发达ALS而参加五个美国未来的军团两个注册控制相同的年龄、性别和种族。脂肪酸,表示为总脂肪酸的比例,由气液色谱法测定。内部和之间的样本系数变化范围从& lt; 1%到10%在十一多不饱和脂肪酸。性别multivariable-adjusted比率(RR)的ALS发病率或死亡率被Cox比例风险回归估计,使用反变量权重。结果:患者较高的等离子体亚麻酸有较低的风险ALS:年龄匹配factor-adjusted分析,RR = 0.63(95%置信区间CI:[0.41, 0.96]趋势p = 0.018)比较四分位数4象限1。调整身体质量指数、吸烟、教育获得,血浆尿酸盐和其他n−3多不饱和脂肪酸,没有实质性改变结果。进一步调整花生四烯酸减毒发现女性而不是男性(趋势p = 0.002)。 Individuals with higher plasma arachidonic acid had a higher risk of ALS: in age- and matching factor-adjusted analyses, RR=1.64 (95% CI: [1.06, 2.54] p-for-trend=0.018) comparing quartile 4 to quartile 1. Adjustment for BMI, smoking, education attained, plasma urate, other n−6 and n−3 polyunsaturated fatty acids did not materially change the findings.Conclusions: Polyunsaturated fatty acid profile may modulate the risk of ALS. Consumption of foods high in alpha-linolenic acid may help prevent or delay the onset of ALS.Disclosure: Dr. O'Reilly has nothing to disclose. Dr. Bjornevik has nothing to disclose. Dr. McCullough has nothing to disclose. Dr. Kolonel has nothing to disclose. Dr. Le Marchand has nothing to disclose. Dr. Manson has nothing to disclose. Dr. Ascherio has nothing to disclose. ER -