% 0期刊文章%大卫·g·穆尼奥斯% Ka彝族古%一个汤姆·A·施魏策尔%科琳·e·费舍尔% T异常频谱的夜间行为阿尔兹海默症病理负载(P1.181) % D J神经病学2018% % P P1.181 % V 90% N 15补充% X目的:探讨载脂蛋白的影响(ApoE)基因型和路易小体的频率不正常的夜间行为(N +)在一个大集团的主题与已知的阿尔茨海默病(AD)负载。首页背景:ApoEɛ4等位基因是一个强大的广告的风险因素,AD患者和夜间障碍是常见的。设计/方法:数据来自国家老年痴呆症协调中心(NACC)数据库,使用2368年尸检的情况下神经库存调查问卷(NPI-Q)收购前不到两年。受试者分类如下:Braak阶段V / VI和CERAD频繁神经炎的斑块高负载广告(已经)Braak阶段III / IV和温和派CERAD中间加载广告(IAD)和Braak阶段0 / I / II和罕见的CERAD低负载广告(NAD)。丢弃的情况下两者之间矛盾的措施。结果:N +更常见NAD和组相比,网络成瘾组,但无显著差异被发现在NAD和。作为一个总体趋势,ɛ4运营商显示N +频率大于非承运人。N +和ɛ4之间显著相关,独立于路易小体的存在,在NAD女性被发现。N +显著与杂合的IADɛ4有关男性和纯合子的女性,但只在那些路易小体。路易小体的存在,不管ApoE基因型,与N +在IAD男性。只有女性ɛ4航空公司有更高的患病率路易小体。Conclusions: The effect of ApoE ɛ4 on the frequency of N+ is modulated by gender and AD pathology severity. Female NAD ɛ4 carriers show a higher prevalence of N+, an effect independent of AD pathology and Lewy bodies. A single ɛ4 copy is required in IAD males, but two in HAD females to increase N+ frequency; Lewy bodies are involved in both cases.Study Supported by:Canadian Institutes of Health Research (CIHR).Disclosure: Dr. Munoz has nothing to disclose. Dr. Koo has nothing to disclose. Dr. Schweizer has nothing to disclose. Dr. Fischer has nothing to disclose. %U