@article {PreziosaP1.393作者={保罗Preziosa朱塞佩·A·拉米雷斯和艾瑞卡Bozzolo Patrizia Rovere-Querini和安吉洛曼马西莫菲利皮主持和玛丽亚·A·罗卡},title ={受损的大脑结构连接体在系统性红斑狼疮和多发性硬化症患者:图论研究(P1.393)},体积={90}={15}补充数量,elocation-id = {P1.393} ={2018},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:探讨大脑结构连接体的地形组织系统性红斑狼疮(SLE)患者与健康对照组比较(HC)和复发缓和多发性硬化(名RRMS)患者。首页背景:焦点在常规MRI大脑异常,普遍异常正常白质和灰质和功能性皮质的变化描述系统性红斑狼疮患者有或没有临床证据的神经(NP)的参与。设计/方法:大脑dual-echo, 3 d t1和扩散张量(DT)来自32个系统性红斑狼疮患者的MRI扫描与NP-SLE(12), 32名RRMS患者和32 HC,匹配对年龄、性别和疾病持续时间(病人)。116皮层和皮层下脑区之间的结构连接矩阵估计,全球和节点网络指标计算。结果:HC相比,系统性红斑狼疮和MS患者显示下降(p \ < 0.0001)强度、传递性、全球效率和增加整个网络的平均路径长度。这些异常是不太严重的女士在系统性红斑狼疮患者(p从0.005到0.01)。类似的中心被发现在所有三个组。在系统性红斑狼疮和MS患者,所有中心显示从\降低强度相比,HC (p < 0.0001 ~ 0.001)。系统性红斑狼疮相比,医学患者显示低强度中心位于fronto-temporo-parieto-occipital皮层,皮层下核(包括丘脑、尾状核和壳核)和小脑(p从0.001到0.05)。没有发现显著差异在全球和区域的措施比较系统性红斑狼疮患者和没有神经参与。结论:重大异常的全球和区域结构连接措施发生系统性红斑狼疮和MS患者,建议分散结构完整性的破坏。这种异常的程度更严重的女士比系统性红斑狼疮患者。披露:Preziosa博士没有披露。 Dr. Ramirez has nothing to disclose. Dr. Bozzolo has nothing to disclose. Dr. Rovere-Querini has nothing to disclose. Dr. Manfredi has nothing to disclose. Dr. Filippi has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen Idec, Merk-Serono, Novartis, Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in an editorial capacity for Journal of Neurology. Dr. Filippi has received research support from Biogen Idec, Novartis, Teva Pharmaceutical Industries. Dr. Rocca has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen Idec, Novartis, Teva Neurosciences and Genzyme.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/90/15_Supplement/P1.393}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }