TY - T1的纵向下滑演讲的具体语义变体原发性进行性失语(svPPA) (P3.192) JF -神经学乔-神经学六世- 90 - 15补充SP - P3.192盟Katheryn兄弟盟沙龙灰非盟-莫里格罗斯曼Y1 2018/04/10 UR - http://n.ne首页urology.org/content/90/15_Supplement/P3.192.abstract N2 -目的:纵向研究评估这样演讲的具体语义变体原发性进行性失语(svPPA)下降随着时间的推移和灰质萎缩。背景:语义记忆被认为是全球svPPA受损。然而,一些研究表明,损失的具体名词的知识比抽象名词更严重——这种现象被称为“逆转的具体性效应”。具体名词损害的大小svPPA被认为是由于左腹侧颞叶萎缩的程度,它支持视觉特性具体名词的知识重要的表示。我们检查萎缩之间的关系和具体性svPPA演讲的下降。设计/方法:引起半结构化的语音样本,11 svPPA病人被要求描述Cookie盗窃图片在两个时间点,平均13.55个月的基线和跟踪。对于每一个主题,名词产生被评为发布的具体使用规范。t1加权磁共振成像(MRI)的灰质(GM)萎缩时基线性能在7 svPPA情况下可用。通用汽车与32名健康对照组相比。回归分析在svPPA检查萎缩在基线预测性能跟踪,局限于地区的萎缩。结果:混合效应模型表明,疾病持续时间影响具体的演讲svPPA(χ2 (1)= 5.83,p = 0.015)。相对于控制,svPPA病人表现出减少通用汽车在双边颞叶。 Regression analyses in svPPA revealed that GM atrophy in left fusiform gyrus and left middle temporal gyrus at baseline was related to significantly decreased concreteness of speech at followup.Conclusions: Impairment for concrete nouns in svPPA becomes more severe over time, and impaired visual feature knowledge due to atrophy of visual association cortex in the left temporal lobe may contribute to this decline.Study Supported by:This work was supported in part by NIH (AG017586, AG038490, AG053488) and the Wyncote Foundation.Disclosure: Dr. Cousins has nothing to disclose. Dr. Ash has nothing to disclose. Dr. Grossman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with GE Whitney. Dr. Grossman has received personal compensation in an editorial capacity for Neurology. ER -