TY-JOURT1-停止稳定MS病人疾病修改处理首页(S8.008) JF - Neurology JO - Neurology VL - 90 IS - 15 Supplement SP - S8.008 AU - Bianca Weinstock-Guttman AU - Katelyn Kavak AU - Caila Vaughn AU - Andrew Goodman AU - Patricia Coyle AU - Lauren Krupp AU - Malcolm Gottesman AU - Keith Edwards AU - Michael Lenihan AU - Allan Perel AU - Robert Zivadinov Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/S8.008.abstract N2 - Objective: To assess the effects of treatment discontinuation on disability worsening in multiple sclerosis (MS) patients with long disease duration.Background: Patients with MS (pwMS) with a stable disease course might view continued treatment as unnecessary.常推荐老化人群停止治疗,但缺少清晰数据支持这一点。 设计/方法:停止疾病修改治疗法(DMTs)和没有恢复治疗(n=193)的病人从纽约州MSC承建集团提取并跨三次时间点跟踪(约3.8年)。稳定残疾课程定义不变,从中断前访问(时间1)到DMT终止访问(时间2)不差一分加分(如果EDSS <6.0或小于0.5分加分)。EDSS访问停止治疗分数2比DDSS使用这些标准中断DMT访问分数3残疾恶化率比对有或无稳定病程的病人使用奇差分析中止前额外分析基于年龄