PT -期刊文章AU - Elisa Canu AU - Federica Agosta AU -亚历山德拉Tomic盟Nataša DragaševićAU -滨Svetel盟-弗拉基米尔Kostic盟-马西莫菲利皮主持TI -分解Affective-Cognitive网络功能肌张力障碍(P6.047) DP - 2018年4月10 TA -神经病学PG - P6.047 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/P6首页.047.short 4100 - //www.ez-admanager.com/content/90/15_Supplement/P6.047.full所以Neurology2018 4月10;90 AB -目的:探索affective-cognitive网络的作用(ACN)在两个功能肌张力障碍的临床表型(FD):固定(FixFD)和移动肌张力障碍(MobFD)。背景:ACN包括腹内侧前额叶皮层等脑区(vmPFC),右颞交界处(rTPJ),背侧前扣带皮层(通道)、双边丘脑背内侧核(MDN)和小脑认知的一部分(Cog-cerebellum,小腿i ii)参与计划运动的机构,认知控制和意识。ACN改变可能与FD的病理生理学。设计/方法:静息状态(RS)功能性核磁共振获得40 FD患者(12 FixFD;28 MobFD)和43个健康对照组(14年轻FixFD-age-matched (yHC)和29个旧MobFD-age-matched (oHC)]。RS功能连通性评估和比较组间使用seed-based方法与vmPFC rTPJ,通道,两国MDN和Cog-Cerebellum种子。结果:HC相比,两组的患者显示增强的FC Cog-Cerebellum和两国之间的关联顶叶皮层,与更大的增强FixFD与MobFD相比。上凸轮轴相比,MobFD显示减少了FC vmPFC之间,左MDN,双边前PFC;和增强FC双边MDN和两国之间关联顶叶和视觉皮层。 Compared to yHC, FixFD showed reduced FC between vmPFC, right MDN, rTPJ, dACC and bilateral PFC and premotor cortex; and between dACC and right primary motor cortex and insula. Compared to MobFD, FixFD patients showed enhanced FC between dACC and primary and premotor cortices.Conclusions: The two FD phenotypes showed similar ACN altered connectivity with PFC reflecting patient difficulties in cognitive control and motor inhibition. However, sensorimotor connectivity was more disrupted in the FixFD group, with unique involvement of dACC and rTPJ, crucial for emotion regulation, awareness and sense of agency. These findings suggest that brain functional architecture could modulate the phenotypic expression of FD.Study Supported by: Ministry of Education and Science Republic of Serbia (Grant #175090).Disclosure: Dr. Canu has nothing to disclose. Dr. Agosta has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with EXCEMED— Excellence in Medical Education. Dr. Tomic has nothing to disclose. Dr. Dragaþevic has nothing to disclose. Dr. Svetel has nothing to disclose. Dr. Kostic has received personal compensation in an editorial capacity for Novartis and Boehriner Ingelheim. Dr. Kostic has received research support from Valeant, Stada, Novartis and Boehriner Ingelheim. Dr. Filippi has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen Idec, Merk-Serono, Novartis, Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in an editorial capacity for Journal of Neurology. Dr. Filippi has received research support from Biogen Idec, Novartis, Teva Pharmaceutical Industries.