TY - T1的无症状的颈动脉狭窄的颈动脉血管再生和医疗管理:Crest-2 (S50.006) JF -神经学乔-神经学六世- 90 - 15补充SP - S50.006 AU -詹姆斯Meschia盟Brajesh Lal AU -乔治·霍首页华德AU -加里Roubin盟-罗伯特·布朗AU -凯文·巴雷特盟Seemant查图尔维迪盟- Marc Chimowitz AU -巴特Demaerschalk AU -维吉尼亚霍华德盟——约翰·休斯顿盟——罗纳德·Lazar盟Moy -韦斯利·摩尔盟克劳迪娅AU -谭雅图兰盟珍妮弗Voeks AU -托马斯王硕Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/S50.006.abstract N2 -目的:提供Crest-2临床试验的总结,和研究进展。背景:超过100000的颈动脉血管再生程序完成每年在美国无症状的颈动脉狭窄。颈动脉内膜切除手术的安全性(CEA)和颈动脉支架植入(CAS),和药物治疗的疗效改变动脉粥样硬化的进展有所改善。因此,之前的随机试验的适用性在无症状的颈动脉狭窄一直质疑目前的治疗决策。设计/方法:研究所资助的目的CREST-2是比较CEA和强化药物治疗与IMT (n = 1240),中科院和IMT与IMT (n = 1240),通过两个并行随机临床试验在大约120个医疗中心,包括与NIH-StrokeNet合作。复合主要结果是任何中风或死亡后44天内随机化或侧缺血性中风之后4年。二次结果包括认知功能,通过计算机辅助电话访谈中定期评估。IMT定向集中,包括严格控制血压(收缩压目标& lt;140毫米汞柱)和胆固醇(低密度脂蛋白目标& lt;70 mg / dl)和生活方式指导。结果:10月8日,2017年,选址委员会已经批准了159个站点,其中113名(71%)有至少一个病人。 The Surgical and Interventional Management Committees have credentialed 370 surgeons and 160 interventionists. An additional 182 interventionists have been approved to submit additional cases via the CREST-2 Companion Registry. 784 patients have been randomized, 383(49%) patients in the endarterectomy trial, and 401 (51%) patients in the stent trial.Conclusions: CREST-2 is designed to identify the best approach for asymptomatic carotid stenosis. An update will be provided regarding the numbers of patients randomized, centers certified, as well as surgeons and interventionists fully approved. The CREST-2 Registry will provide the option of CAS while enhancing interventionists’ credentials for participation in CREST-2.Disclosure: Dr. Meschia has nothing to disclose. Dr. Lal has nothing to disclose. Dr. Howard has nothing to disclose. Dr. Roubin has nothing to disclose. Dr. Brown has nothing to disclose. Dr. Barrett has nothing to disclose. Dr. Chaturvedi has received personal compensation in an editorial capacity for NEJM Journal Watch Neurology. Dr. Chaturvedi has received research support from Boehringer Ingelheim. Dr. Chimowitz has nothing to disclose. Dr. Demaerschalk has nothing to disclose. Dr. Howard has nothing to disclose. Dr. Huston has nothing to disclose. Dr. Lazar has nothing to disclose. Dr. Moore has nothing to disclose. Dr. Moy has nothing to disclose. Dr. Turan has nothing to disclose. Dr. Voeks has nothing to disclose. Dr. Brott has nothing to disclose. ER -