RT期刊文章SR电子T1小脑变性和进步与艾滋病毒感染有关的共济失调(P1.078)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P1.078 VO 90 15补充A1玛丽亚Thereza Drumond指出伽马A1蒂亚戈首页卡多佐淡水河谷A1 Jose Luiz Pedroso A1 Gustavo里巴斯A1胡里奥Kristochik A1玛丽亚克里斯蒂娜•芬克domingue达席尔瓦A1奥古斯托。塞萨尔Penalva de Oliveira A1赫利奥阿方索Teive A1奥兰多Barsottini年2018 UL //www.ez-admanager.com/content/90/15_Supplement/P1.078.abstract AB目的:描述一系列情况的四个患者小脑变性与艾滋病毒感染有关。背景:神经系统疾病的光谱与人类免疫缺陷病毒(HIV)是非常广泛的。它可以分为那些源于直接感染艾滋病毒,机会性感染的神经系统,原发性中枢神经系统淋巴瘤和其他恶性肿瘤,治疗的毒性,others1。常见的神经退行性条件包括艾滋病毒触发,包括HIV-dementia复杂和肌萎缩性脊髓侧索硬化症(ALS) 2、3。一些报告显示进步的共济失调之间的关系和艾滋病患者小脑变性。共济失调在艾滋病患者的具体病理生理机制还不是很清楚。设计/方法:一群共济失调患者(N = 1.050)是评估从2008年到2017年,为了确定共济失调的病因。这个示例包括几个原因遗传和零星的共济失调。结果:我们发现4例呈现进步的共济失调,小脑萎缩和积极的艾滋病毒测试。二、神经退化原因和最常见的遗传性共济失调(Friedreich和脊髓小脑的共济失调)被排除在外。没有病人机会性感染或肿瘤可能证明小脑参与。样品进行了重复PCR(血液、脑脊液和尿液)和JC病毒都是负面的。 We had no evidence to consider that ataxia symptoms were caused by Highly active antiretroviral therapy (HAART).Conclusions: HIV infection should be investigated in adult patients with undetermined sporadic progressive pure ataxia and cerebellar atrophy. Pathophysiological may involve cerebellar degeneration instead of autoimmune or medication toxic effects, similar to neurodegeneration observed in ALS and HIV-dementia complex.Disclosure: Dr. DRUMOND GAMA has nothing to disclose. Dr. Vale has nothing to disclose. Dr. Pedroso has nothing to disclose. Dr. Ribas has nothing to disclose. Dr. Kristochik has nothing to disclose. Dr. Domingues da Silva Fink has nothing to disclose. Dr. Penalva de Oliveira has nothing to disclose. Dr. Teive has nothing to disclose. Dr. Barsottini has nothing to disclose.

map