TY - T1的血管反应性和微观结构变化与神经认知症状慢性创伤性脑损伤(S49.001) JF -神经学乔-神经学六世- 90 - 15补充SP - S49.001盟莎拉·伍德森盟- Margalit Haber盟弗兰克Amyot AU -凯利Fleshner盟艾丽卡西尔弗曼盟Kimbra肯尼AU -卡罗首页尔·摩尔盟Yi-Yu周盟Dzung Pham AU -迈克尔Sangobowale盟雷蒙Diaz-Arrastia Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/S49.001.abstract N2 -目的:探索结构完整性之间的关系,微血管功能,神经认知表现慢性创伤性脑损伤(TBI)。背景:之前的研究表明多病灶的血管,在慢性创伤性脑损伤的显微结构的损伤。这些损伤和慢性神经认知症状之间的关系尚不清楚。设计/方法:功能性MRI-Blood-Oxygen-Level(粗体显示)和扩散张量成像(DTI) 27日进行慢性创伤性脑损伤的主题和14名健康对照组。每个图像被分割成解剖与Freesurfer感兴趣的区域(ROI)。脑血管反应性(表格),脑血流量(CBF)、分数各向异性(FA)和平均扩散系数在每个地区(MD)的含量。非参数枪兵ρ相关性计算(Version 7、Graphpad Inc .)比较选择32 ROI和分数从7神经心理评估(Trail-Making测试(TMT) A和B,加州言语学习测试,广泛成就测验,和韦氏成人智力量表)。Post-concussive症状(pc)评估使用Inventory-Somatic短暂的症状和Rivermead后震荡问卷。结果:表格在颞额叶、扣带,和全球白质(WM)地区几个神经精神评估分数有显著相关性。之间存在显著的负相关表格和TMT-B下颞叶(正确的:Rs =−0.42;p = 0.03,左:Rs =−0.39; p=0.05). Positive correlations were seen between FA and neuropsychiatric assessments in frontal, cingulate, and white matter regions. Global CVR, grey matter CVR, and CVR values in subcortical regions (hippocampus, amygdala, thalamus, caudate, putamen) were positively correlated with PCS self-report (p<0.05). Few significant correlations were seen between neuropsychological testing variables and CBF or MD.Conclusions: Vascular reactivity and microstructural integrity within multiple regions of the brain are associated with neurocognitive symptoms in chronic TBI patients. While CVR is decreased in chronic TBI, this study demonstrates that increased CVR, especially within subcortical regions, is associated with more PCS. Further studies are needed to explore the effects of cerebral vascular injury in chronic TBI.Disclosure: Dr. Woodson has nothing to disclose. Dr. Haber has nothing to disclose. Dr. Amyot has nothing to disclose. Dr. Fleshner has nothing to disclose. Dr. Silverman has nothing to disclose. Dr. Kenney has nothing to disclose. Dr. Moore has nothing to disclose. Dr. Chou has nothing to disclose. Dr. Pham has nothing to disclose. Dr. Sangobowale has nothing to disclose. Dr. Diaz-Arrastia has nothing to disclose. ER -