RT期刊文章SR电子T1之间的联系(¹⁸F] AV1451τ的宠物和CSF措施τ病理临床样本摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP e282 O首页P e290 10.1212 / WNL。90签证官0000000000004860是4 A1 Renaud La乐趣A1 Alexandre Bejanin A1安妮·m·费根A1 Nagehan Ayakta A1苏珊娜·l·贝克A1维克多利亚Bourakova A1亚当·l·拳击手A1 Jungho Cha A1安娜Karydas A1吉娜杰罗姆A1安妮马斯河A1阿什利犯罪A1扎卡里·a·米勒A1詹姆斯p奥尼尔A1朱莉Pham A1霍华德·j·罗森A1理查德·蔡A1艾德丽安诉Visani A1布鲁斯·l·米勒A1 William j . Jagust A1吉尔·d·Rabinovici年2018 UL //www.ez-admanager.com/content/90/4/e282.abstract AB目的评估τ的流体和成像生物标记物之间的关系在临床病理和比较他们的诊断效用异类样本。首页方法对53例(28与临床阿尔茨海默病(AD)和25 non-AD临床神经退行性诊断)接受β-amyloid (Aβ)和τ([18 f] AV1451)宠物和腰椎穿刺。脑脊液生物标志物(Aβ42,总τ(t-tau),和磷酸化τ[p-tau])是衡量multianalyte免疫测定(AlzBio3)。接收机算子特性分析比较歧视non-AD Aβ-positive广告的条件在生物标记。脑脊液生物标记和宠物之间的相关性标准摄入值比率(SUVR)评估使用跳过皮尔森相关系数。Voxelwise分析运行评估区域CSF-PET关联。结果[18 f] AV1451-PET皮质SUVR p-tau显示,优秀的Aβ-positive广告之间的歧视和non-AD条件(曲线下的面积0.92 - -0.94;≤0.83其他CSF措施),达到83%的分类一致。在完整的样例中,皮质[18 f] AV1451与脑脊液生物标记,最强烈p-tau t-tau (r = 0.75 vs 0.57和0.49−Aβ42)。限制患者Aβ-positive广告时,[18 f] AV1451 SUVR相关适度p-tau和t-tau (r = 0.46)但不是Aβ42 (r = 0.02)。 On voxelwise analysis, [18F]AV1451 correlated with CSF p-tau in temporoparietal cortices and with t-tau in medial prefrontal regions. Within AD, Mini-Mental State Examination scores were associated with [18F]AV1451-PET, but not CSF biomarkers.Conclusion [18F]AV1451-PET and CSF p-tau had comparable value for differential diagnosis. Correlations were robust in a heterogeneous clinical group but attenuated (although significant) in AD, suggesting that fluid and imaging biomarkers capture different aspects of tau pathology.Classification of evidence This study provides Class III evidence that, in a clinical sample of patients with a variety of suspected neurodegenerative diseases, both CSF p-tau and [18F]AV1451 distinguish AD from non-AD conditions.Aβ=β-amyloid; AD=Alzheimer disease; AUC=area under the curve; CI=confidence interval; GM=gray matter; LBNL=Lawrence Berkeley National Laboratory; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; p-tau=phosphorylated tau; PHF-tau=paired helical filaments of tau; PiB=Pittsburgh compound B; ROC=receiver operating characteristic; SPM12=Statistical Parametric Mapping 12; SUVR=standard uptake value ratio; t-tau=total tau; UCSF=University of California San Francisco

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