% 0期刊文章% Renaud La乐趣%一个Alexandre Bejanin %安妮·m·费根% Nagehan Ayakta %一个维克多利亚Bourakova苏珊娜·l·贝克% %亚当·l·拳击手%一个安娜Karydas Jungho Cha % %吉娜杰罗姆%一个安妮马斯河%阿什利犯罪%扎卡里·A·米勒%詹姆斯·p·奥尼尔%朱莉Pham %霍华德·j·罗森%艾德丽安诉Visani理查德·蔡% %一个布鲁斯·l·米勒% William j . Jagust %吉尔·d·Rabinovici % T之间的联系(18F] AV1451τ的宠物和CSF措施τ病理临床样本% D R 10.1212 / WNL 2018%。0000000000004860 % J首页神经病学% P e282-e290 % V 90% N 4% X客观评估τ的流体和成像生物标记物之间的关系在临床病理和比较他们的诊断效用异类样本。方法对53例(28与临床阿尔茨海默病(AD)和25 non-AD临床神经退行性诊断)接受β-amyloid (Aβ)和τ([18 f] AV1451)宠物和腰椎穿刺。脑脊液生物标志物(Aβ42,总τ(t-tau),和磷酸化τ[p-tau])是衡量multianalyte免疫测定(AlzBio3)。接收机算子特性分析比较歧视non-AD Aβ-positive广告的条件在生物标记。脑脊液生物标记和宠物之间的相关性标准摄入值比率(SUVR)评估使用跳过皮尔森相关系数。Voxelwise分析运行评估区域CSF-PET关联。结果[18 f] AV1451-PET皮质SUVR p-tau显示,优秀的Aβ-positive广告之间的歧视和non-AD条件(曲线下的面积0.92 - -0.94;≤0.83其他CSF措施),达到83%的分类一致。在完整的样例中,皮质[18 f] AV1451与脑脊液生物标记,最强烈p-tau t-tau (r = 0.75 vs 0.57和0.49−Aβ42)。限制患者Aβ-positive广告时,[18 f] AV1451 SUVR相关适度p-tau和t-tau (r = 0.46)但不是Aβ42 (r = 0.02)。 On voxelwise analysis, [18F]AV1451 correlated with CSF p-tau in temporoparietal cortices and with t-tau in medial prefrontal regions. Within AD, Mini-Mental State Examination scores were associated with [18F]AV1451-PET, but not CSF biomarkers.Conclusion [18F]AV1451-PET and CSF p-tau had comparable value for differential diagnosis. Correlations were robust in a heterogeneous clinical group but attenuated (although significant) in AD, suggesting that fluid and imaging biomarkers capture different aspects of tau pathology.Classification of evidence This study provides Class III evidence that, in a clinical sample of patients with a variety of suspected neurodegenerative diseases, both CSF p-tau and [18F]AV1451 distinguish AD from non-AD conditions.Aβ=β-amyloid; AD=Alzheimer disease; AUC=area under the curve; CI=confidence interval; GM=gray matter; LBNL=Lawrence Berkeley National Laboratory; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; p-tau=phosphorylated tau; PHF-tau=paired helical filaments of tau; PiB=Pittsburgh compound B; ROC=receiver operating characteristic; SPM12=Statistical Parametric Mapping 12; SUVR=standard uptake value ratio; t-tau=total tau; UCSF=University of California San Francisco %U //www.ez-admanager.com/content/neurology/90/4/e282.full.pdf